High intensity interval training to improve insulin sensitivity in type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of high intensity interval training (HIIT) on insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). It focuses on how exercise can enhance glucose disposal in skeletal muscle, which is often impaired in T2DM patients due to insulin resistance. Participants aged 45 to 75 with a diagnosis of T2DM will engage in a structured exercise program while being monitored for changes in insulin sensitivity and plasma glucose levels. The study aims to understand the relationship between exercise, insulin sensitivity, and fat accumulation in the liver.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants are able to provide signed and dated written informed consent prior to any study specific procedures
* Aged ≥ 45 and ≤ 75 years
* BMI: 25-35 kg/m2
* Diagnosed as T2DM patients for at least 1 year and not longer than 5 years
* HbA1c ≥ 6.5% and ≤ 8.5%
* Fasting blood glucose \<130 mg/dL
* Women are post-menopausal (\>1 year cessation of menses),
* Being stable on medication use of metformin and/or sulfonylurea derivatives for the previous 3 months or more and other medication naïve.

Exclusion Criteria:

* Type 1 diabetes
* Patients with congestive heart failure and and/or severe renal and or liver insufficiency
* Contraindications for MRI/MRS examination
* Active diabetic foot
* Polyneuropathy or retinopathy
* Signs of active liver or kidney dysfunction
* BMI \>35 kg/m2
* Exogeneous insulin therapy
* Use of antidiabetic medication other than metformin or sulfonylurea derivatives treatment within 3 months before screening
* Use of SGLT2 inhibitors
* Unstable body weight (variations \>5kg in the last 3 months)
* Ongoing weight loss diet or use of weight loss agents
* Uncontrolled hypertension
* Engagement in regular exercise program or any other medical condition that will impede the safe performance of the experiments

Where it's running

• Finis Terrae University
  Santiago, Chile Recruiting

Study contacts

• Principal investigator: Rodrigo Mancilla, PhD — Finis Terrae University
• Study coordinator: Rodrigo Mancilla, PhD
• Email: rmancilla@uft.cl
• Phone: +56953676588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.