High-Intensity Interval Training for School-age Children at Risk of Heart Disease
The Effect of High-Intensity Interval Training(HIIT) on Cardio-metabolic Indicators in School-age Children With High Cardiovascular Diseases Risk--a Randomised Intervention Trial
This study is testing if high-intensity interval training can help school-age children at risk for heart disease improve their health and stick with the exercise over time.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 336 (estimated) |
| Ages | 7 Years to 18 Years |
| Sex | All |
| Sponsor | Children's Hospital of Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06416488 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of high-intensity interval training (HIIT) on school-age children who are at high risk for cardiovascular disease and metabolic disorders. It aims to assess the health benefits of HIIT, including improvements in body composition, lipid health, and blood pressure regulation. The study also focuses on the long-term adherence and acceptability of HIIT in this population, which could inform future health promotion strategies. By addressing the lack of evidence regarding HIIT's impact on overweight and obese children, this intervention could provide valuable insights into effective exercise regimens for improving cardiovascular and metabolic health.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 7-18 years who exhibit at least one cardio-metabolic abnormality, such as prediabetes or lipid abnormalities.
Not a fit: Patients with severe underlying health conditions, such as heart failure or cancer, may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce cardio-metabolic risks in school-age children, promoting healthier lifestyles and preventing chronic diseases.
How similar studies have performed: Previous studies have shown positive outcomes with HIIT in improving health metrics in children, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 7-18 years at baseline. * At least one of the following cardio-metabolic abnormalities: 1. Prediabetes (Impaired fasting glucose: 5.6 ≤ fasting blood glucose level ≤ 6.9 mmol/L; or Impaired glucose tolerance: 7.8 ≤ blood glucose level after 2 hours postprandial ≤ 11.0 mmol/L). 2. Lipid abnormalities (High-density lipoprotein cholesterol ≤ 1.04 mmol/L; or Low-density lipoprotein cholesterol ≥ 3.37 mmol/L; or Triglycerides ≥ 1.70 mmol/L, or Total cholesterol ≥ 5.18 mmol/L). 3. Elevated blood pressure (Systolic/diastolic blood pressure consistently higher than the 90th percentile for gender, age, and height; or systolic/diastolic blood pressure ≥ 120/80 mmHg). * Written consent from participants and their guardians. Exclusion Criteria: * Previously diagnosed with heart failure, severe malnutrition, immune deficiency, liver or kidney disease, cancer, or other diseases deemed unsuitable for participation. * Taking weight loss drugs, or undergone weight loss surgery. * Attending behavior-based intervention programs (exercise or diet) within a year. * Regular HIIT (at least once per week). * Secondary obesity, such as neuropsychiatric disorders, endocrine disorders, sleep apnea syndrome, or other conditions. * Unable to take interventions due to health conditions, such as joint diseases, fractures, injuries. * Other situations unsuitable for participation.
Where this trial is running
Shanghai, Shanghai Municipality
- Children's Hospital of Fudan University — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Wennan He
- Email: wennanhe@fudan.edu.cn
- Phone: +8664932921
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.