High-intensity breathing exercises for asthma patients
High-intensity Inspiratory Muscle Training in Patients With Asthma
This study is testing whether high-intensity breathing exercises can help people with severe asthma breathe better and improve their overall quality of life compared to low-intensity exercises.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 34 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Istanbul Medipol University Hospital Academic / other |
| Locations | 1 site (Istanbul, Üsküdar) |
| Trial ID | NCT06516848 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of high-intensity and low-intensity inspiratory muscle training combined with standard pulmonary rehabilitation on patients with asthma. Participants diagnosed with severe persistent asthma will be randomized into two groups to receive either high or low intensity training over an 8-week period. The training includes a structured program of inspiratory muscle exercises, breathing exercises, and walking training, with sessions conducted online and supervised by a physiotherapist. The aim is to assess improvements in respiratory muscle function, exercise capacity, and overall quality of life.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 with severe persistent, non-allergic asthma under treatment and control.
Not a fit: Patients with recent respiratory infections, significant smoking history, or high body mass index may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance respiratory function and quality of life for asthma patients.
How similar studies have performed: Previous studies have shown positive outcomes with inspiratory muscle training in respiratory conditions, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being between the ages of 18-65 years * Having been diagnosed with severe persistent, non-allergic asthma by a pulmonologist in accordance with the Global Initiative for Asthma (GINA) guideline criteria, * Patients with type 2 inflammation markers. According to accepted standards; peripheral eosinophils \<150/µL and/or negative skin prick test and/or total IgE \<30 kU/L * Bronchodilator response (\>12% or 200 mL improvement in FEV1% predicted following inhalation of 400 mg salbutamol) * Those who were diagnosed at least 6 months ago and are under follow-up and treatment, and/or patients whose asthma is under control Exclusion Criteria: * Having recently had a respiratory tract infection recently (within the last month), * Having a smoking history of more than 10 pack-years or having a history of smoking within 6 months after quitting smoking * Having received oral corticosteroid treatment in the last 4 weeks, * Having a Body Mass Index \>35, * Eosinophilic Granulomatosis Polyangiitis (EGPA) and Allergic Bronchopulmonary Aspergillosis (ABPA), * Vasculitis, * History of malignancy, * Pregnancy, * Previous lung surgery, use of long-term oxygen therapy * Having accompanying restrictive lung diseases (advanced kyphoscoliosis, ankylosing spondylitis) and neuromuscular diseases (myasthenia gravis, muscular dystrophies, myopathies) that will prevent healthy respiratory function testing and rehabilitation. * Having conditions such as cognitive dysfunction, mental retardation, dementia that make it difficult to implement the protocol or interpret the study results
Where this trial is running
Istanbul, Üsküdar
- Esra Pehli̇van — Istanbul, Üsküdar, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Cahidenur Koçak
- Email: cahidekocak@gmail.com
- Phone: +90 216 777 8 777
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.