High-flow oxygen therapy with nebulized medication for asthma attacks in the emergency department

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of high-flow oxygen therapy combined with nebulized beta-2-agonists using a vibrating mesh nebulizer for patients experiencing moderate to severe asthma exacerbations in the emergency department. The study aims to improve treatment outcomes by comparing standard nebulization methods with the innovative vibrating mesh approach. Patients will be monitored for respiratory rate, peak flow, and oxygen saturation to assess the efficacy of the interventions. The goal is to provide a more effective treatment option for acute asthma exacerbations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age equal or over 18 years
* admitted in an Emergency Department with a clinical suspicion of acute exacerbation of asthma according to the Global Initiative for Asthma (GINA) criteria.
* with at least one of the following criteria 60mn after a first treatment by beta-2 agonist adrenergic nebulization with 3 x 5 mg of terbutaline:

  * Respiratory rate over 22 breaths/min
  * Peak flow \< 50% of predictive normal value
  * SpO2 \< 95% in room air
  * Signs of severe asthma exacerbation (at least one criteria):

Talks in word, Agitation, Sits hunched forwards, Accessory muscles in use

* Free subject, without guardianship or curatorship or subordination
* Patients benefiting from a Social Security scheme or benefiting from it through a third party
* Informed consent signed by the patient after clear and honest information about the study

Exclusion Criteria:

* Acute exacerbation of asthma during the last 30 days
* Clinical suspicion of acute exacerbation of asthma due to anaphylaxis, pneumothorax, pneumomediastinum, pneumonia or atelectasis.
* At least ONE of the following serious signs: drowsiness, confusion, auscultatory silence
* Clinical suspicion of another pathology that could explain the respiratory failure such as heart failure, laryngeal obstruction, pulmonary embolism, etc
* Patients with neurological (Glasgow \< 13) or hemodynamical failure (Mean Arterial Pressure \< 65 mmHg)
* contraindication to treatment with a beta-2-adrenergic agonist
* History of hypersensitivity (allergy) to terbutaline or any of the constituents
* Contraindication to OHD
* Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, people assessed GIR1 or GIR 2 (AGGIR grid), adults under legal protection
* Pregnant or breastfeeding women, Women at age to procreate and not using effective contraception

Where it's running

• University Hospital of Poitiers
  Poitiers, France, France Recruiting

Study contacts

• Principal investigator: Nicolas MARJANOVIC, MD PHD — CHU Poitiers
• Study coordinator: Nicolas MARJANOVIC, MD PHD
• Email: nicolas.marjanovic@chu-poitiers.fr
• Phone: 0549441873

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.