Clinical trial Recruiting at 1 site Interventional Ages 18 and up

High-flow nasal oxygen with monitored anesthesia for EBUS bronchoscopy

Official title: Prospective Study to Evaluate High Flow Nasal Cannula With Monitored Anesthesia Care

Run by Cooper Norcross Health · NCT05203328 · Data updated 2026-11-12

This study will test whether using a Vapotherm high-flow nasal cannula with monitored anesthesia care during EBUS bronchoscopy reduces procedure interruptions, low-oxygen episodes, and procedure time for adults having EBUS.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment198 (estimated)
SponsorCooper Norcross Health
Academic / other
Locations1 site (Camden, New Jersey)
StatusRecruiting
StartedFebruary 1, 2022
Main results expectedMarch 2026
Study endsMay 2026
Registry record updatedSeptember 25, 2025
Trial IDNCT05203328 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age >18) with lung cancer scheduled for EBUS bronchoscopy under monitored anesthesia care who meet baseline oxygenation and surgical/anticoagulation criteria are ideal candidates.

Probably not a fit

Patients with baseline oxygen saturation under 90% on room air, prior nasal surgery or facial fractures, pregnancy, or anticoagulation that cannot be stopped are excluded and unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for EBUS bronchoscopy with monitored anesthesia care at a single center will receive either a Vapotherm high-flow nasal cannula or a regular nasal cannula during the procedure. Researchers will prospectively compare the number and duration of hypoxic episodes, frequency of procedure interruptions, and total procedural time between the two oxygen-delivery methods. Standard inclusion and exclusion criteria apply, excluding patients with prior nasal surgery, significant facial trauma, baseline low oxygen saturation, pregnancy, or anticoagulation that cannot be held. Data will be collected during the procedure and analyzed to determine whether high-flow oxygen improves intra-procedural stability and efficiency.

Why it matters

Potential benefit: If successful, using high-flow nasal oxygen could reduce drops in oxygen levels and interruptions during EBUS, making the procedure safer and potentially shorter.

How similar studies have gone: Other studies of high-flow nasal oxygen during bronchoscopy or procedural sedation have shown reduced desaturation and improved oxygenation in some settings, but evidence specifically for EBUS is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age\>18 years
* patient undergoing EBUS bronchoscopy with moderate conscious sedation.

Exclusion Criteria:

* subjects with previous nasal surgeries
* subjects with oxygen saturation \<90% on room air prior to procedure
* subjects who are pregnant
* subjects with known facial fractures or recent facial trauma
* subjects on any anticoagulation that cannot be discontinued prior to the procedure

Where it's running

  • Cooper University Hospital
    Camden, New Jersey, United States
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.