High-flow nasal oxygen with monitored anesthesia for EBUS bronchoscopy
Official title: Prospective Study to Evaluate High Flow Nasal Cannula With Monitored Anesthesia Care
Run by Cooper Norcross Health · NCT05203328 · Data updated 2026-11-12
This study will test whether using a Vapotherm high-flow nasal cannula with monitored anesthesia care during EBUS bronchoscopy reduces procedure interruptions, low-oxygen episodes, and procedure time for adults having EBUS.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 198 (estimated) |
| Sponsor | Cooper Norcross Health Academic / other |
| Locations | 1 site (Camden, New Jersey) |
| Status | Recruiting |
| Started | February 1, 2022 |
| Main results expected | March 2026 |
| Study ends | May 2026 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT05203328 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age >18) with lung cancer scheduled for EBUS bronchoscopy under monitored anesthesia care who meet baseline oxygenation and surgical/anticoagulation criteria are ideal candidates.
✕Probably not a fit
Patients with baseline oxygen saturation under 90% on room air, prior nasal surgery or facial fractures, pregnancy, or anticoagulation that cannot be stopped are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults scheduled for EBUS bronchoscopy with monitored anesthesia care at a single center will receive either a Vapotherm high-flow nasal cannula or a regular nasal cannula during the procedure. Researchers will prospectively compare the number and duration of hypoxic episodes, frequency of procedure interruptions, and total procedural time between the two oxygen-delivery methods. Standard inclusion and exclusion criteria apply, excluding patients with prior nasal surgery, significant facial trauma, baseline low oxygen saturation, pregnancy, or anticoagulation that cannot be held. Data will be collected during the procedure and analyzed to determine whether high-flow oxygen improves intra-procedural stability and efficiency.
Why it matters
Potential benefit: If successful, using high-flow nasal oxygen could reduce drops in oxygen levels and interruptions during EBUS, making the procedure safer and potentially shorter.
How similar studies have gone: Other studies of high-flow nasal oxygen during bronchoscopy or procedural sedation have shown reduced desaturation and improved oxygenation in some settings, but evidence specifically for EBUS is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age\>18 years * patient undergoing EBUS bronchoscopy with moderate conscious sedation. Exclusion Criteria: * subjects with previous nasal surgeries * subjects with oxygen saturation \<90% on room air prior to procedure * subjects who are pregnant * subjects with known facial fractures or recent facial trauma * subjects on any anticoagulation that cannot be discontinued prior to the procedure
Where it's running
-
Cooper University Hospital
Camden, New Jersey, United States Recruiting
Study contacts
- Study coordinator: Wissam Abouzgheib, MD
- Email: Abouzgheib-Wissam@cooperhealth.edu
- Phone: (800) 826-6737
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
ePRO in advanced lung cancer: emotional distress, brain metastasis, and symptom burden
This study tests how patients with advanced lung cancer—some with brain metastases—report emotional distress and symptoms over time using electronic questionnaires.
-
Urine VOC Test to Detect Lung Cancer in Never Smokers
A urine test that looks for volatile compounds is tested to see if it can help detect lung cancer in adults who have never smoked.
-
SI-B036 safety test in advanced and metastatic solid tumors
This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.
-
Guaraná Supplement for Cancer-Related Fatigue in People Undergoing Treatment
This study tests whether taking guaraná capsules helps reduce cancer-related fatigue and improve quality of life in adults with breast, lung, colorectal, or gastric cancer who are actively receiving treatment.
-
ENPP1/cGAS and FAP in Solid Tumors in Vietnamese Patients
This Vietnam-based study will test ENPP1, cGAS, and FAP expression in archived tumor samples from Vietnamese adults with solid cancers using immunohistochemistry.
-
Olive oil before lung cancer surgery to see if it lowers chylothorax
This study tests whether drinking 40 mL of extra-virgin olive oil a few hours before lung cancer surgery can reduce chylothorax after tumor removal.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.