High-flow nasal oxygen versus face mask oxygen for sedated gastroscopy in people with visceral obesity
Official title: High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy: A Randomized Controlled Trial.
Run by Shanghai Zhongshan Hospital · NCT07159022 · Data updated 2026-11-12
This test sees if using high-flow nasal oxygen instead of a standard face mask keeps oxygen levels better during sedated gastroscopy for people with visceral obesity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai) |
| Status | Recruiting |
| Started | August 31, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | July 31, 2026 |
| Registry record updated | December 1, 2025 |
| Trial ID | NCT07159022 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with visceral obesity (BMI ≥28 and BRI ≥5.46), ASA class I–III, who are scheduled for sedated gastroscopy are the ideal candidates.
✕Probably not a fit
People without visceral obesity or those with contraindications such as recent thoracic surgery, nasal/nasopharyngeal disease, tracheostomy, severe unstable heart or pulmonary conditions, bleeding disorders, or pregnancy are unlikely to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an unblinded randomized controlled comparison of high-flow nasal cannula (HFNC) oxygenation versus standard face mask oxygenation in patients with visceral obesity undergoing sedated gastroscopy. Eligible adults have BMI ≥28 and a body roundness index (BRI) ≥5.46 and are ASA class I–III. Patients are randomly assigned to receive HFNC or mask oxygen during the procedure and monitored for oxygenation, hypoxemic events, and related airway complications. The trial is being conducted at Zhongshan Hospital in Shanghai and focuses on intra-procedural respiratory outcomes.
Why it matters
Potential benefit: If successful, HFNC could reduce episodes of low oxygen and improve safety during sedated gastroscopy in people with visceral obesity.
How similar studies have gone: Some prior small studies and clinical experience suggest HFNC can improve oxygenation during sedated endoscopy in obese patients, but high-quality evidence remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA class ≤Ⅲ * Visceral obesity（body mass index≥28 and BRI ≥5.46） * Patients who will undergo sedated gastroscopy Exclusion Criteria: * Life-threatening heart disease or acute myocardial infarction within 6 weeks * Presence of pneumothorax or pulmonary bullae, pulmonary embolism, pulmonary oedema * Upper respiratory tract infection * Presence of tracheostomy * Nasal or nasopharyngeal diseases * Coagulation disorders or a tendency of nose bleeding * Pregnancy * Recent (within 1 week) thoracic surgery * Emergent procedure or surgery * Allergy to drugs used during the procedure * Unwillingness to participate in the study
Where it's running
-
Zhongshan Hospitla
Shanghai, China Recruiting
Study contacts
- Study coordinator: Wenling Zhao
- Email: zhao.wenling@zs-hospital.sh.cn
- Phone: +86-18321299017
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.