High-density EEG mapping of brain connectivity in Friedreich's ataxia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, exploratory multicenter pilot will use high-density electroencephalography (HD-EEG) to map resting-state and task-based brain connectivity in 30 people with genetically confirmed Friedreich's ataxia and SARA <30. Participants will undergo HD-EEG recordings at rest and during an upper-limb motor task alongside comprehensive neuropsychological testing and clinical scales (SARA, mFARS). The study will correlate connectivity metrics with cognitive profiles and clinical severity and explore relationships with rehabilitation-related changes. The approach aims to identify neurophysiological biomarkers of cerebello-cortical network dysfunction in FRDA.

Why it matters

Who can join: the full rules

Inclusion criteria:

* age between 8 and 60 years;
* genetic diagnosis of FRDA: presence of guanine-adenine trinucleotide (GAA) expansion in the two alleles of the fratassin gene, GAA1 and GAA2;
* score on the Scale for the Assessment and Rating of Ataxia (SARA) \< 30;
* ability to take part in a neuropsychological assessment in Italian.

Exclusion criteria:

* age different from the range 8-60 years;
* diagnosis of acquired ataxia or other genetic ataxias;
* SARA scale score ≥ 30;
* inability to take part in an Italian-language neuropsychological assessment

Where it's running

• IRCCS Eugenio Medea / Associazione la Nostra Famiglia
  Conegliano, Treviso, Italy Recruiting

Study contacts

• Principal investigator: Gabriella Paparella, Medical Doctor — IRCCS E. Medea / Associazione la Nostra Famiglia
• Study coordinator: Gabriella Paparella, Medical Degree
• Email: gabriella.paparella@lanostrafamiglia.it
• Phone: +39 04389062

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.