Hidden malaria infections and mosquito dynamics in Odisha
Official title: The Center for the Study of Complex Malaria in India (CSCMi 3.0): Hidden Plasmodium Infections: Reservoirs, Impact, and Biomarker Discovery
Run by London School of Hygiene and Tropical Medicine · NCT07770048 · Data updated 2026-11-12
This study follows a large group of people in rural Odisha to see how many have malaria infections without symptoms and how this hidden reservoir relates to ongoing transmission.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Months to 69 Years |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | London School of Hygiene and Tropical Medicine Academic / other |
| Locations | 2 sites (Bhubaneswar, Odisha and 1 other locations) |
| Status | Recruiting |
| Started | May 2, 2025 |
| Main results expected | May 31, 2029 |
| Study ends | May 31, 2029 |
| Registry record updated | August 18, 2026 |
| Trial ID | NCT07770048 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are residents aged 12 months to 69 years from selected rural villages in Odisha who can provide informed consent and comply with study procedures.
✕Probably not a fit
Individuals unlikely to benefit are those who do not develop or carry asymptomatic infections or who do not participate in follow-up visits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, community-based cohort tracks about 3,000 residents over time to measure prevalence and incidence of asymptomatic and sub-patent Plasmodium infections. It will compare microscopy, rapid tests, and PCR to identify false negatives and species misidentifications. The research also investigates how vector species, density, and behavior relate to persistent transmission in areas with different malaria patterns. By examining parasite, human, and mosquito factors together, the study aims to understand drivers of residual transmission in Odisha. The work is conducted under CSCMi-3 and involves multiple local institutions and international collaboration.
Why it matters
Potential benefit: If successful, findings could inform targeted strategies to identify hidden infections and reduce residual malaria transmission in endemic communities.
How similar studies have gone: Previous work suggests asymptomatic and sub-patent infections contribute to transmission, but detailed vector–parasite interactions in Odisha are not fully characterized and this study builds on that evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals 12 months to 69 years, all social classes, and all types of health status will be enrolled Exclusion Criteria: * Individuals unable or unwilling to provide informed consent (or parental consent/assent for minors) Individuals unable to comply with study procedures or follow-up visits according to investigator judgement
Where it's running
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ICMR-National Institute of Health Research
Bhubaneswar, Odisha, India Recruiting -
Community Welfare Society Hospital (CWSH)
Raurkela, Odisha, India Recruiting
Study contacts
- Principal investigator: Samuel Wassmer, PhD — London School of Hygiene & Tropical Medicine, London
- Study coordinator: Samuel Wassmer, PhD
- Email: sam.wassmer@lshtm.ac.uk
- Phone: +44 7930357115
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.