Hetrombopag for improving platelet recovery in children with neuroblastoma after stem cell transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of hetrombopag in promoting platelet engraftment in children diagnosed with neuroblastoma who are undergoing autologous hematopoietic stem cell transplantation. Participants will receive hetrombopag daily for six weeks or until their platelet count exceeds 100 x 10^9/L. The primary objective is to determine whether this medication can enhance the recovery of platelet levels post-transplantation, which is crucial for preventing complications related to low platelet counts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age\<18 years old;
* Diagnosed as neuroblastoma;
* ECOG ≤ 2;
* First time receiving autologous hematopoietic stem cell transplantation;
* The subjects or their legal guardians agree to participate and sign the informed consent form.

Exclusion Criteria:

* ALT/AST \> 3 ULN, or TBIL \> 1.5 ULN;
* Have experienced congestive heart failure, arrhythmia, peripheral arteriovenous thrombosis requiring medication treatment within one year prior to enrollment, or have experienced myocardial infarction or cerebral infarction within three months prior to enrollment;
* Suffering from thromboembolic diseases;
* Other situations that are not suitable for inclusion in the study determined by researchers.

Where it's running

• Department of Stem Cell Transplantation, Beijing Children's Hospital, Capital Medical University
  Beijing, China Recruiting

Study contacts

• Study coordinator: Dr. Yang
• Email: yangjundabby@outlook.com
• Phone: 86-010-59617614

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.