Hesperidin for fatigue and cognitive symptoms in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a remote, randomized, double-blind, placebo-controlled, parallel-group trial that assigns adults with MS to 500 mg/day hesperidin or a matching placebo for 12 weeks. The primary outcome is change in fatigue (Modified Fatigue Impact Scale) with secondary outcomes including cognitive performance and mood measured at baseline and week 12. Data will be analysed using linear mixed-effects models comparing change from baseline with fixed effects for group, time, and the group × time interaction and a participant-level random intercept. The rationale is based on preclinical EAE models suggesting hesperidin has anti-inflammatory and antioxidant effects, but human randomized data are limited.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Multiple Sclerosis, Aged 18 years or older.

Exclusion Criteria:

* Known food allergies, intolerances, or significant gastrointestinal (GI) problems, Participants under the age of 18 years.

Where it's running

• FHMLS, Nutrition Lab
  Swansea, Wales, United Kingdom Recruiting

Study contacts

• Principal investigator: Hayley A Young, PHD — Swansea University
• Study coordinator: Hayley Young, PhD
• Email: h.a.young@swansea.ac.uk
• Phone: +44 (0) 1792 295908

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.