Helping families share hereditary cancer risk information and access genetic testing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional effort uses a virtual Cascade Genetic Testing Platform to deliver web-based communication, educational materials, and navigation support to probands with a confirmed pathogenic germline variant and their adult biological relatives. Probands must have been evaluated at the University of Michigan Cancer Genetics Clinic; relatives must be adults, English-speaking, have internet access, and not have completed clinical germline testing. The platform aims to overcome logistic and communication barriers that limit cascade testing uptake, with outcomes measured over a shortened 6-month follow-up. Participants complete surveys and use informational/communication tools designed to increase relatives' participation in genetic testing and follow-up with genetics providers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* PROBANDS: Clinically confirmed autosomal dominant pathogenic germline variant (PGV) associated with a hereditary cancer syndrome
* PROBANDS: Previous evaluation by the University of Michigan (U-M) Cancer Genetics Clinic
* PROBANDS: ≥ 18 years old
* PROBANDS: Able to speak and read English
* PROBANDS: Access to the internet
* RELATIVES: Biological relative of proband
* RELATIVES: ≥ 18 years old
* RELATIVES: Able to speak and read English
* RELATIVES: Access to the internet
* RELATIVES: Have not completed germline genetic testing, per self-report at baseline

Exclusion Criteria:

* RELATIVES: Prior clinical germline genetic testing for cancer or already have an upcoming appointment scheduled with a genetics provider, per self-report at baseline

Where it's running

• University of Michigan Comprehensive Cancer Center
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Elena M Stoffel — University of Michigan Rogel Cancer Center
• Study coordinator: MiGHT HelpLine
• Email: MiGHT-Cascade@med.umich.edu
• Phone: (734) 764-4044

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.