Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Heart rate variability in BPPV

Official title: Evaluation of Autonomic Function Using Short-Term Heart Rate Variability in Patients With Benign Paroxysmal Positional Vertigo: A Prospective Case-Control Study

Run by Istanbul Aydın University · NCT07472998 · Data updated 2026-11-12

This project will test whether short-term heart rate variability measurements differ between adults with BPPV and age- and sex-matched healthy controls.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment104 (estimated)
SponsorIstanbul Aydın University
Academic / other
Locations1 site (Istanbul, Küçükçekmece)
StatusRecruiting
StartedApril 1, 2026
Main results expectedAugust 1, 2026
Study endsSeptember 1, 2026
Registry record updatedApril 16, 2026
Trial IDNCT07472998 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults (18+) with BPPV confirmed by Dix-Hallpike or Roll testing, no known cardiac disease, and able to give informed consent, plus age- and sex-matched healthy adults without vestibular disorders as controls.

Probably not a fit

People under 18, those with cardiac disease or arrhythmias, or anyone taking medications that directly affect HRV are unlikely to benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective case-control study compares short-term heart rate variability (HRV) between adults with clinically confirmed benign paroxysmal positional vertigo (BPPV) and matched healthy controls. Recordings will focus on parasympathetic indicators such as RMSSD and the coefficient of variation of RR intervals (COV RR/R). People with known cardiac disease, arrhythmias, or on medications that affect HRV are excluded to reduce confounding. The approach aims to clarify whether altered vagal activity accompanies BPPV onset or recurrence.

Why it matters

Potential benefit: If successful, the findings could provide an objective autonomic marker linked to BPPV that may inform prevention or personalized management strategies.

How similar studies have gone: Some preliminary work links stress and autonomic changes to vestibular symptoms, but objective HRV data specifically in BPPV is limited and relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* BPPV Group

Age 18 years or older

Clinical diagnosis of benign paroxysmal positional vertigo (BPPV) confirmed by positional testing (Dix-Hallpike and/or Roll test) with positional nystagmus

No known history of cardiac disease

Ability and willingness to provide written informed consent

Healthy Control Group

Age 18 years or older

No history of vertigo or known vestibular disorder

Age- and sex-matched to the BPPV group

No known history of cardiac disease

Ability and willingness to provide written informed consent

Exclusion Criteria:

* Age younger than 18 years

Inability to provide informed consent or impaired mental capacity

Known arrhythmia, heart failure, ischemic heart disease, or other clinically significant cardiac disorder

Use of medications that may directly affect heart rate variability, including beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs, digoxin, systemic corticosteroids, centrally acting sympatholytic agents, or psychotropic medications that may influence autonomic balance

Active infection or systemic inflammatory disease

Where it's running

  • Medicalpark Florya Hospital
    Istanbul, Küçükçekmece, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.