Heart rate variability in BPPV
Official title: Evaluation of Autonomic Function Using Short-Term Heart Rate Variability in Patients With Benign Paroxysmal Positional Vertigo: A Prospective Case-Control Study
Run by Istanbul Aydın University · NCT07472998 · Data updated 2026-11-12
This project will test whether short-term heart rate variability measurements differ between adults with BPPV and age- and sex-matched healthy controls.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 104 (estimated) |
| Sponsor | Istanbul Aydın University Academic / other |
| Locations | 1 site (Istanbul, Küçükçekmece) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | August 1, 2026 |
| Study ends | September 1, 2026 |
| Registry record updated | April 16, 2026 |
| Trial ID | NCT07472998 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (18+) with BPPV confirmed by Dix-Hallpike or Roll testing, no known cardiac disease, and able to give informed consent, plus age- and sex-matched healthy adults without vestibular disorders as controls.
✕Probably not a fit
People under 18, those with cardiac disease or arrhythmias, or anyone taking medications that directly affect HRV are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective case-control study compares short-term heart rate variability (HRV) between adults with clinically confirmed benign paroxysmal positional vertigo (BPPV) and matched healthy controls. Recordings will focus on parasympathetic indicators such as RMSSD and the coefficient of variation of RR intervals (COV RR/R). People with known cardiac disease, arrhythmias, or on medications that affect HRV are excluded to reduce confounding. The approach aims to clarify whether altered vagal activity accompanies BPPV onset or recurrence.
Why it matters
Potential benefit: If successful, the findings could provide an objective autonomic marker linked to BPPV that may inform prevention or personalized management strategies.
How similar studies have gone: Some preliminary work links stress and autonomic changes to vestibular symptoms, but objective HRV data specifically in BPPV is limited and relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * BPPV Group Age 18 years or older Clinical diagnosis of benign paroxysmal positional vertigo (BPPV) confirmed by positional testing (Dix-Hallpike and/or Roll test) with positional nystagmus No known history of cardiac disease Ability and willingness to provide written informed consent Healthy Control Group Age 18 years or older No history of vertigo or known vestibular disorder Age- and sex-matched to the BPPV group No known history of cardiac disease Ability and willingness to provide written informed consent Exclusion Criteria: * Age younger than 18 years Inability to provide informed consent or impaired mental capacity Known arrhythmia, heart failure, ischemic heart disease, or other clinically significant cardiac disorder Use of medications that may directly affect heart rate variability, including beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs, digoxin, systemic corticosteroids, centrally acting sympatholytic agents, or psychotropic medications that may influence autonomic balance Active infection or systemic inflammatory disease
Where it's running
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Medicalpark Florya Hospital
Istanbul, Küçükçekmece, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Dastan Temirbekov, assistan professor
- Email: dasekeeee@gmail.com
- Phone: 05314013014
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.