Heart rate variability in BPPV
Evaluation of Autonomic Function Using Short-Term Heart Rate Variability in Patients With Benign Paroxysmal Positional Vertigo: A Prospective Case-Control Study
This project will test whether short-term heart rate variability measurements differ between adults with BPPV and age- and sex-matched healthy controls.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 104 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Istanbul Aydın University Academic / other |
| Locations | 1 site (Istanbul, Küçükçekmece) |
| Trial ID | NCT07472998 on ClinicalTrials.gov |
What this trial studies
This prospective case-control study compares short-term heart rate variability (HRV) between adults with clinically confirmed benign paroxysmal positional vertigo (BPPV) and matched healthy controls. Recordings will focus on parasympathetic indicators such as RMSSD and the coefficient of variation of RR intervals (COV RR/R). People with known cardiac disease, arrhythmias, or on medications that affect HRV are excluded to reduce confounding. The approach aims to clarify whether altered vagal activity accompanies BPPV onset or recurrence.
Who should consider this trial
Good fit: Ideal candidates are adults (18+) with BPPV confirmed by Dix-Hallpike or Roll testing, no known cardiac disease, and able to give informed consent, plus age- and sex-matched healthy adults without vestibular disorders as controls.
Not a fit: People under 18, those with cardiac disease or arrhythmias, or anyone taking medications that directly affect HRV are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the findings could provide an objective autonomic marker linked to BPPV that may inform prevention or personalized management strategies.
How similar studies have performed: Some preliminary work links stress and autonomic changes to vestibular symptoms, but objective HRV data specifically in BPPV is limited and relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BPPV Group Age 18 years or older Clinical diagnosis of benign paroxysmal positional vertigo (BPPV) confirmed by positional testing (Dix-Hallpike and/or Roll test) with positional nystagmus No known history of cardiac disease Ability and willingness to provide written informed consent Healthy Control Group Age 18 years or older No history of vertigo or known vestibular disorder Age- and sex-matched to the BPPV group No known history of cardiac disease Ability and willingness to provide written informed consent Exclusion Criteria: * Age younger than 18 years Inability to provide informed consent or impaired mental capacity Known arrhythmia, heart failure, ischemic heart disease, or other clinically significant cardiac disorder Use of medications that may directly affect heart rate variability, including beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs, digoxin, systemic corticosteroids, centrally acting sympatholytic agents, or psychotropic medications that may influence autonomic balance Active infection or systemic inflammatory disease
Where this trial is running
Istanbul, Küçükçekmece
- Medicalpark Florya Hospital — Istanbul, Küçükçekmece, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Dastan Temirbekov, assistan professor
- Email: dasekeeee@gmail.com
- Phone: 05314013014
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.