Clinical trial Recruiting at 1 site Observational

Haploidentical stem cell transplantation with early ATG and low-dose cyclophosphamide

Official title: Haploidentical Hematopoietic Stem Cell Transplantation With Early Antithymocyte Globulin and Low Dose Post-transplant Cyclophosphamide

Run by Samsung Medical Center · NCT06041893 · Data updated 2026-11-12

This study is testing if giving a special medication and a lower dose of chemotherapy right after a stem cell transplant can help patients who don't have a matched donor recover better.

Quick facts

Study typeObservational
SexAll
Enrollment20 (estimated)
SponsorSamsung Medical Center
Academic / other
Drugs / interventionscyclophosphamide
Locations1 site (Seoul)
StatusRecruiting
StartedMay 29, 2023
Main results expectedJuly 5, 2025
Study endsDecember 31, 2025
Registry record updatedDecember 3, 2024
Trial IDNCT06041893 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients undergoing haploidentical hematopoietic stem cell transplantation at Samsung Medical Center.

Probably not a fit

Patients who are unable to provide consent or do not meet the eligibility criteria will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of early administration of anti-thymocyte globulin (ATG) and low-dose post-transplant cyclophosphamide in patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HCT). The research is conducted at Samsung Medical Center and aims to define optimal strategies for haplo-HCT in patients who lack a matched donor. By focusing on a single center, the study seeks to provide detailed insights into the outcomes associated with this specific treatment approach.

Why it matters

Potential benefit: If successful, this approach could improve transplant outcomes and reduce complications for patients undergoing haploidentical stem cell transplantation.

How similar studies have gone: While haploidentical stem cell transplantation is increasingly used, the specific combination of early ATG and low-dose cyclophosphamide is still being explored, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients undergoing haploidentical hematopoietic stem cell transplantation with ATG and low-dose post-transplant cyclophosphamide conditioning at the department of pediatrics, Samsung Medical Center.

Exclusion Criteria:

* A clinical trial subject (legal representative, if applicable) who do not consent or is unable to give written consent.

Where it's running

  • Samsung Medical Center
    Seoul, South Korea
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.