Gut microbiome and physical performance: antibiotics and fecal transplants in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will monitor healthy adults who exercise regularly for up to one month, tracking activity, glucose, and microbiome changes. In the first phase, participants will wear CGMs, log activity, and provide stool and buccal samples for microbiome analysis. In the second phase, they are randomized to receive antibiotics or placebo for seven days. In the third phase, they receive autologous fecal microbiota transplantation (or placebo) across two days. A fourth phase reassesses with another round of transplantation for those who had antibiotics, alongside placebo groups. The study integrates microbiome profiling with metabolic and activity measurements to explore links between microbiome composition and physical performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age - 20-55
* Are used to exercise in aerobic sports (running, swimming, 'zumba', ball games, functional training, surfing, tennis, wrestling ext.).
* Exercise at least twice a week, for a minimum duration of the last 6 months.

Exclusion Criteria:

* Consumption of antibiotics (PO) or probiotics 3 months prior to the first day of the experiment.
* Diagnosis of type 1 or type 2 diabetes.
* Pregnancy, fertility treatments, breastfeeding women six months prior to enrollment and during the study.
* Chronic disease-under the discretion of the study medical team (e.g. AIDS, Cushing syndrome, Chronic kidney disease (CKD), acromegaly, hyperthyroidism etc.)
* Cancer and recent anticancer treatment
* Psychiatric disorders
* Coagulation disorders
* Gastrointestinal disorders
* Bariatric surgery
* Alcohol or substance abuse
* Any physical condition precluding the completion of a routine effort test
* Allergy to Flagyl (Metronidazole) and/ or Ciprodex (Ciprofloxacin)

Where it's running

• Weizmann Institute of Science
  Rehovot, Israel Recruiting

Study contacts

• Principal investigator: Ilan Youngster, Dr. — Assaf-Harofeh MC, Bee'r Yaakov Israel
• Study coordinator: Ilan Youngster, Dr.
• Email: youngsteri@asaf.health.gov.il
• Phone: +972-50630119

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.