Gum recession in adults with and without prior orthodontic treatment
Official title: Gingival Recessions in Orthodontically Treated and Untreated Adult Patients: a Prospective Study
Run by Universitaire Ziekenhuizen KU Leuven · NCT07445555 · Data updated 2026-11-12
We will test which patient and tooth factors increase the chance of gum recession in adults who have or have not had orthodontic treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Leuven) |
| Status | Recruiting |
| Started | November 15, 2023 |
| Main results expected | July 15, 2026 |
| Study ends | September 1, 2027 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT07445555 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older, classified ASA I–II, with or without previous orthodontic treatment and without periodontal disease or excluded medications are the intended participants.
✕Probably not a fit
Patients with active periodontal disease, those taking excluded medications, people with prior radio/chemotherapy, pregnant or breastfeeding individuals, or those with agenesis of lower incisors are excluded and would not benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will record clinical, demographic, periodontal, occlusal, and orthodontic-history parameters in adult patients with and without prior orthodontic treatment to identify features linked to gingival recession. Treated and untreated groups will be compared and site- and patient-level variables such as gingival phenotype, tooth position, brushing trauma, smoking, and frenal attachment will be analyzed. Patients with active periodontal disease, certain medications, prior radio- or chemotherapy, pregnancy or breastfeeding, or agenesis of lower incisors are excluded. The ultimate aim is to produce a practical clinical guideline to estimate the risk of developing post-orthodontic gingival recession.
Why it matters
Potential benefit: If successful, clinicians could better predict who is likely to develop gum recession after orthodontic care and offer tailored prevention or treatment planning.
How similar studies have gone: Previous observational reports have suggested associations between orthodontic treatment and gingival recession but results are inconsistent, so this approach builds on suggestive but not definitive prior findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with or without previous history of orthodontic treatment with and without gingival recessions * ≥ 18 years old * American Society of Anesthesiologists Classification I or II Exclusion criteria: * Patients with history of periodontal disease * taking the following medication: anticoagulants, phenytoin, cyclosporine, nifedipine or calcium channel blockers * Patients with prior history of radio or chemotherapy * Pregnant or breastfeeding patients * Patients with agenesis of one or more lower incisors Exclusion Criteria: Patients with history of periodontal disease Patients taking the following medication: anticoagulants, phenytoin, cyclosporine, nifedipine or calcium channel blockers Patients with prior history of radio or chemotherapy Pregnant or breastfeeding patients Patients with agenesis of one or more lower incisors
Where it's running
-
UZ Leuven
Leuven, Belgium Recruiting
Study contacts
- Principal investigator: Ana Castro — Universitaire Ziekenhuizen KU Leuven
- Study coordinator: Ana Castro
- Email: ana.castro@uzleuven.be
- Phone: +3216332407
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Root coverage using different restorative materials in Class V lesions
This study tests whether using glass ionomer cement, resin composite, or no restoration before root coverage surgery helps people with gum recession and neck lesions
-
Volume-stable collagen matrix vs graft for multiple gingival recessions
This study tests whether a volume-stable collagen matrix can cover exposed roots as well as a traditional graft, in adults with multiple gingival recessions.
-
Gingival recession and its effect on oral health-related quality of life
This project will see how common gingival recession is and whether it affects oral health-related quality of life in adults aged 18–45 who visit a tertiary dental center in Haryana.
-
Comparing a new 3D tunneling technique with a modified coronally advanced tunnel plus connective tissue graft for treating multiple RT2 gingival recession.
This trial will try a new 3D tunneling surgical technique versus a modified coronally advanced tunnel with connective tissue graft to improve root coverage in adults who have multiple RT2 gingival recessions.
-
Using 3D dental imaging to lower gum recession during aligner treatment
This test tries to see if planning aligner treatment with 3D CBCT imaging instead of 2D images can reduce gum recession for adults undergoing dental arch expansion.
-
Volume-stable collagen matrix to cover gum recession on teeth
This test checks whether a new volume-stable collagen matrix can replace a connective tissue graft from the palate to cover buccal gum recessions in adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.