Guiding fluid removal in critically ill patients using bioelectrical impedance analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the effectiveness of using bioelectrical impedance analysis (BIA) to guide fluid removal in critically ill patients undergoing continuous renal replacement therapy (CRRT). It compares two groups: one receiving standard fluid removal prescriptions based on clinical judgment and another guided by the extracellular to total body water ratio measured by BIA. The goal is to determine if this BIA-guided approach leads to better fluid balance and outcomes over a 72-hour period. The study is conducted at a single center, the Amiens-Picardie University Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years
* The patient was hospitalized in the intensive care unit of Amiens-Picardie University Hospital.
* Patient with an increase in fluid balance (TBW \> 5%)
* Patient receiving continuous veno-venous hemofiltration (CVVH) on a PrismaFlexR or PrisMaxR machine, initiated due to oliguria, potassium level \> 6.5 mmol/L, urea level \> 25 mmol/L, or creatinine \> 300 µmol/L and severe metabolic acidosis (pH \< 7.2).
* Hemodynamically stable patient with a mean arterial pressure (MAP) \> 65 mmHg for more than 4 hours with norepinephrine.
* Signed consent to participate in the study by the patient or, if unconscious, their legal representative/next of kin.

Exclusion Criteria:

* Invalid BIA measurements
* Internal device powered by an electrical current (pacemaker, implantable cardioverter-defibrillator, neurostimulator)
* Cardiac arrhythmia (atrial fibrillation, atrial flutter) present at the inclusion
* Chronic dialysis patient
* Moribund patient
* The patient is on extracorporeal mechanical support
* Hemorrhagic shock
* Pregnant woman
* Patient under guardianship or conservators.

Where it's running

• CHRU Amiens
  Salouël, France Recruiting

Study contacts

• Study coordinator: Christophe Beyls, MD
• Email: beyls.christophe@chu-amiens.fr
• Phone: 33 + 03 22 08 78 66

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Urinary Sodium and Chloride Changes and Fluid Overload in Acute Heart Failure

  This study tests whether tracking urinary sodium and chloride during hospitalization can reflect congestion removal and predict short-term outcomes in adults with acute heart failure treated with IV diuretics.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Olot, Girona and 3 other locations · NCT07597512

• Training medical residents to use the Venous Excess Ultrasound (VExUS) score for bedside volume assessment

  This project tests whether in-person or remote training better teaches medical residents to use the VExUS ultrasound score for bedside volume checks in patients with acute heart failure.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07541768

• Urine sodium spot testing to guide diuretic dosing in people with chronic heart failure

  This pilot will test whether a quick urine sodium test can help guide increasing or decreasing loop diuretics for people living with chronic heart failure.

  Recruiting Cardiology Research UBC · Vancouver, British Columbia · NCT07369856

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.