Guiding blood flow management during major abdominal surgery using urethral perfusion index
Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial
This study is testing if keeping track of blood flow in the urethra during major abdominal surgery can help improve overall blood flow to the body compared to regular care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 116 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf Academic / other |
| Locations | 2 sites (Hamburg and 1 other locations) |
| Trial ID | NCT06799832 on ClinicalTrials.gov |
What this trial studies
This pilot trial aims to evaluate whether maintaining a specific urethral perfusion index during major abdominal surgery can improve tissue perfusion compared to standard care. The study will monitor urethral perfusion in patients undergoing elective surgeries lasting at least 120 minutes and will assess the correlation between urethral perfusion index and other vital signs. Additionally, it will explore the relationship between urethral and peripheral perfusion indices. The trial is conducted at a single center, focusing on a specific patient population.
Who should consider this trial
Good fit: Ideal candidates are patients aged 45 and older scheduled for elective major abdominal surgery requiring arterial and urinary catheters.
Not a fit: Patients who are pregnant, undergoing nephrectomy or organ transplantation, or those with prior urethral or bladder surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance patient outcomes by optimizing blood flow management during major surgeries.
How similar studies have performed: While this specific approach is novel, similar studies have explored perfusion monitoring in surgical settings with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * at least 45 years old * scheduled for elective major abdominal surgery (involving visceral organs with an expected duration of at least 120 minutes) * indication for an arterial catheter * indication for an urinary catheter Exclusion Criteria: * Pregnancy * Planned surgery: nephrectomy, liver or kidney transplantation surgery * Patients who previously had surgery on the urethra or bladder * Patients without clinical indication for continuous blood pressure monitoring with an intraarterial catheter
Where this trial is running
Hamburg and 1 other locations
- University Medical Center Hamburg-Eppendorf — Hamburg, Germany (Not_yet_recruiting)
- University Medical Center Hamburg-Eppendorf — Hamburg, Germany (Recruiting)
Study contacts
- Principal investigator: Bernd Saugel, MD — University Medical Center Hamburg Eppendorf, Hamburg, Germany and OUTCOMES RESEARCH Consortium®, Houston, Texas, USA
- Study coordinator: Bernd Saugel, MD
- Email: b.saugel@uke.de
- Phone: +49741052415
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.