Guided transfusion strategy for critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates an individualized red blood cell transfusion strategy based on oxygen extraction ratios in critically ill patients. It aims to optimize transfusion practices by determining the appropriate timing for red blood cell transfusions, potentially improving patient outcomes such as reducing 90-day mortality and the incidence of acute kidney injury. The study will compare this individualized approach to standard European guidelines for transfusion. Eligible patients will have specific hemoglobin levels and vascular access for accurate monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hb levels ≤ 9.0 g/dL (as confirmed through a blood test and/or through blood gas analysis)
* Presence of an arterial line and a central venous line (either jugular or subclavian), with confirmed correct position of the catheter tip at the atrio-caval junction (allowing correct estimation of central venous saturation, ScvO2).

Exclusion Criteria:

* Age \< 18 years;
* Pregnancy
* Clinical evidence of acute bleeding
* Diagnosis of haematological malignancy
* Diagnosis of sickle cell disease, or other diseases exposing the patient to chronic RCBTs
* Acquired or congenital disorders of coagulation
* Patients with ongoing AKI of stage 1 or worse and/or known chronic kidney disease (CKD) of stage G3a or worse, defined as glomerular filtration rate below 60 for a minimum of 3 months

Where it's running

• Hospital Erasme
  Brussels, Belgium Recruiting
• Università di Ferrara
  Ferrara, Ferrara, Italy Recruiting
• Università di Perugia
  Perugia, Italy, Italy Recruiting
• Anestesia e Rianimazione Cardio-Toraco-Vascolare
  Siena, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.