Guided lateral sinus lift using autologous serum albumin with platelet-rich fibrin (Alb-PRF)
Official title: Computer-Guided Lateral Sinus Floor Elevation Using Autologous Serum Albumin/Platelet Rich Fibrin Combined With Serum Albumin Membrane: A Randomized Clinical Study
Run by Kafrelsheikh University · NCT07348094 · Data updated 2026-11-12
This trial will test whether using your own serum albumin combined with platelet-rich fibrin (Alb-PRF) during a guided lateral sinus lift helps bone regrow for adults needing implants in the back upper jaw.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Kafrelsheikh University Academic / other |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Status | Recruiting |
| Started | January 26, 2026 |
| Main results expected | January 30, 2027 |
| Study ends | February 15, 2027 |
| Registry record updated | February 18, 2026 |
| Trial ID | NCT07348094 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) in good general health (ASA I–II) with partial edentulism in the posterior maxilla, native non-augmented bone, horizontal ridge ≥5 mm, vertical ridge 3–6 mm, D2–D3 bone quality, and adequate inter-arch distance are ideal candidates.
✕Probably not a fit
Patients with uncontrolled systemic disease, chronic maxillary sinus pathology, heavy smoking, poor oral hygiene, or insufficient ridge dimensions are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants with partial tooth loss in the posterior maxilla will undergo guided lateral sinus augmentation using stereolithographic guides and digital planning. They will receive one of three approaches: conventional bone graft, Alb-PRF derived from their own blood, or sticky bone, and bone gain will be measured with 3D volumetric CBCT analysis. The protocol emphasizes precise lateral window placement to reduce membrane perforation and to allow simultaneous implant placement when appropriate. Standard inclusion criteria include adults with limited vertical ridge height and adequate horizontal ridge width, while patients with uncontrolled systemic disease or chronic sinus pathology are excluded.
Why it matters
Potential benefit: If successful, using Alb-PRF could reduce or replace the need for foreign bone graft material and enhance bone formation using the patient's own blood products, potentially simplifying sinus lift procedures and improving implant success.
How similar studies have gone: Previous clinical reports of PRF and Alb-PRF in sinus augmentation and guided bone regeneration have shown promising bone-healing and reduced complications, but fully replacing conventional bone grafts is not yet firmly established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and females ≥18 years of age. * ASA I and ASA II. * Patients having partial edentulism in the posterior region of the maxilla. * Edentulous sites consist of native non augmented bone. * Horizontal ridge dimension minimum of 5mm * The vertical ridge dimension 3-6 mm. * Bone quality of D2 or D3. * Enough inter-arch distance. Exclusion Criteria: * \- Patients with uncontrolled systemic diseases. * History of chronic maxillary sinus pathology. * Heavy smokers or patients with poor oral hygiene.
Where it's running
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faculty of dentistry, kafrelsheikh University
Kafr ash Shaykh, Kafrelsheikh, Egypt Recruiting
Study contacts
- Study coordinator: walid elamrousy
- Email: waled_hammed@den.kfs.edu.eg
- Phone: 01229460097
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.