Growth factor versus mineral trioxide aggregate for treating mature permanent molars with irreversible pulpitis in children
Concerned Growth Factor Versus Miniral Trioide Aggregate in Management of Mature Permanent Molar of Children With Irreversible Pulpitis. An 18-month Randomized Control Trial
NA · Minia University · NCT07138287
This compares a growth factor treatment with mineral trioxide aggregate to see which better treats mature permanent molars in children who have irreversible pulpitis.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 9 Years to 16 Years |
| Sex | All |
| Sponsor | Minia University (other) |
| Locations | 1 site (Minya) |
| Trial ID | NCT07138287 on ClinicalTrials.gov |
What this trial studies
Children with a restorable mature permanent molar and a closed apex diagnosed with symptomatic irreversible pulpitis will receive either a concerned growth factor application or mineral trioxide aggregate applied to the affected tooth at Minia University Faculty of Dentistry. The interventions are intended to manage pulpal inflammation and preserve tooth vitality, though specific operative details were not provided. Eligible participants exclude medically compromised children, non-restorable teeth, and necrotic teeth. The study will monitor clinical outcomes such as symptom relief and tooth survival over follow-up, but exact endpoints and timing were not listed.
Who should consider this trial
Good fit: Children with a restorable mature permanent molar that has a closed apex and is diagnosed with irreversible pulpitis are the intended participants.
Not a fit: Medically compromised children, patients with non-restorable teeth, and teeth that are necrotic would not be expected to benefit from these interventions.
Why it matters
Potential benefit: If successful, the approach could preserve the infected tooth's vitality, reduce pain, and decrease the need for more invasive root canal procedures.
How similar studies have performed: Mineral trioxide aggregate is a well-established material with good evidence for pulp therapy, while growth-factor–based approaches are newer and have more limited pediatric data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Permanent Molar with closed Apex and diagnosed with irreversible pulpitis \- Exclusion Criteria: * medically compromised children. * non restorable tooth * Necrotic tooth
Where this trial is running
Minya
- Minya University Faculty of Dentistry — Minya, Egypt (RECRUITING)
Study contacts
- Study coordinator: Mahmoud Mostafa Abdelhakim, Master degree
- Email: mahmoudmostafa100001@gmail.com
- Phone: 201004445513
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.