Growth factor versus mineral trioxide aggregate for treating mature permanent molars with irreversible pulpitis in children
Official title: Concerned Growth Factor Versus Miniral Trioide Aggregate in Management of Mature Permanent Molar of Children With Irreversible Pulpitis. An 18-month Randomized Control Trial
Run by Minia University · NCT07138287 · Data updated 2026-11-12
This compares a growth factor treatment with mineral trioxide aggregate to see which better treats mature permanent molars in children who have irreversible pulpitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 9 Years to 16 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Status | Recruiting |
| Started | July 11, 2025 |
| Main results expected | October 1, 2025 |
| Study ends | September 1, 2026 |
| Registry record updated | August 22, 2025 |
| Trial ID | NCT07138287 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children with a restorable mature permanent molar that has a closed apex and is diagnosed with irreversible pulpitis are the intended participants.
✕Probably not a fit
Medically compromised children, patients with non-restorable teeth, and teeth that are necrotic would not be expected to benefit from these interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Children with a restorable mature permanent molar and a closed apex diagnosed with symptomatic irreversible pulpitis will receive either a concerned growth factor application or mineral trioxide aggregate applied to the affected tooth at Minia University Faculty of Dentistry. The interventions are intended to manage pulpal inflammation and preserve tooth vitality, though specific operative details were not provided. Eligible participants exclude medically compromised children, non-restorable teeth, and necrotic teeth. The study will monitor clinical outcomes such as symptom relief and tooth survival over follow-up, but exact endpoints and timing were not listed.
Why it matters
Potential benefit: If successful, the approach could preserve the infected tooth's vitality, reduce pain, and decrease the need for more invasive root canal procedures.
How similar studies have gone: Mineral trioxide aggregate is a well-established material with good evidence for pulp therapy, while growth-factor–based approaches are newer and have more limited pediatric data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Permanent Molar with closed Apex and diagnosed with irreversible pulpitis \- Exclusion Criteria: * medically compromised children. * non restorable tooth * Necrotic tooth
Where it's running
-
Minya University Faculty of Dentistry
Minya, Egypt Recruiting
Study contacts
- Study coordinator: Mahmoud Mostafa Abdelhakim, Master degree
- Email: mahmoudmostafa100001@gmail.com
- Phone: 201004445513
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.