Gradual versus intermittent tourniquet release during upper limb surgery in people with high blood pressure
Official title: The Effect of Gradual Versus Intermittent Release of Tourniquet on Mean Arterial Blood Pressure in Hypertensive Patients Undergoing Upper Limb Orthopedic Surgeries: A Blinded Randomized Controlled Study
Run by Kasr El Aini Hospital · NCT07290504 · Data updated 2026-11-12
This trial will test whether gradual or intermittent tourniquet release better prevents sudden blood pressure and acid-base changes in people with high blood pressure having upper-limb orthopedic surgery under general anesthesia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 68 (estimated) |
| Sponsor | Kasr El Aini Hospital Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | December 13, 2025 |
| Main results expected | November 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | August 5, 2026 |
| Trial ID | NCT07290504 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with well-controlled hypertension on medication for more than three months who are scheduled for elective upper-limb orthopedic surgery requiring a tourniquet for at least 30 minutes and have a BMI between 18.5 and 29.9 without significant additional surgical risks.
✕Probably not a fit
Patients with uncontrolled hypertension, ASA status above II, multiple or emergency orthopedic procedures, BMI outside the specified range, or contraindications to tourniquet use are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial enrolls hypertensive patients scheduled for elective upper-limb orthopedic surgery under standardized general anesthesia. Patients are randomized to either gradual tourniquet deflation (decreasing pressure by 50 mmHg every 30 seconds until complete release within 3 minutes) or intermittent deflation (cycles of 10 seconds full deflation then 50 seconds reinflation repeated until final release). Key measurements include mean arterial pressure and arterial blood gas/acid-base parameters before and after tourniquet release, with ventilation and anesthetic management kept consistent. Deflation is performed using sealed randomization envelopes with the research anesthesiologist blinded to group assignment while an anesthesia technician carries out the allocated technique.
Why it matters
Potential benefit: If one method shows fewer blood pressure swings and better acid-base stability, adopting that deflation approach could reduce perioperative cardiovascular and metabolic stress for hypertensive patients.
How similar studies have gone: Previous reports document hemodynamic and metabolic changes after tourniquet release and some have tested staged deflation methods, but direct randomized comparisons specifically in controlled hypertensive patients are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hypertensive patients (controlled on medical treatment more than three months) * Patients scheduled for upper limb orthopedic surgeries using a tourniquet for at least 30 min. * BMI from 18.5 to 29.9 Exclusion Criteria: * Patient refusal * ASA physical status \> II * Multiple orthopedic surgeries * Emergency surgeries * Patient with relative contraindications for tourniquet use
Where it's running
-
Cairo university hospitals
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Khaled Sarhan, MD
- Email: khaled.sarhan@kasralainy.edu.eg
- Phone: +201020067816
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.