Goat milk vs cow milk digestive tolerance
Digestive Tolerance and Nutrient Absorption Kinetics of Goat Milk Versus Cow Milk in Individuals With Reported Cow's Milk Intolerance : a Controlled Single-blinded Crossover Trial
This will test whether people who have trouble with cow's milk feel better after drinking goat's milk.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement Academic / other |
| Locations | 1 site (Bobigny) |
| Trial ID | NCT07239856 on ClinicalTrials.gov |
What this trial studies
This randomized, single-blind crossover study compares digestive symptoms and the post-meal handling of nutrients after drinking labeled goat milk versus cow milk. Two groups of adults (those reporting intolerance to cow's milk but not goat's milk, and those tolerant to both) each consume both milks in masked meals separated by at least one month. Stable isotope labeling of the milks is used to track postprandial nutrient kinetics while participants report digestive discomfort during the test period. The design aims to link symptom differences with measurable differences in digestion and nutrient absorption.
Who should consider this trial
Good fit: Adults in good general health who either report intolerance to cow's milk but not goat's milk, or who tolerate both milks, and who can attend in-person visits and provide informed consent.
Not a fit: People with known food allergies, diagnosed cow's-milk allergy, significant chronic diseases, pregnancy, anemia below the specified thresholds, or those unable to attend the hospital visits are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, people who react to cow's milk might be able to switch to goat's milk and experience less digestive discomfort.
How similar studies have performed: Previous research is limited and mixed, with some small studies suggesting goat milk may be easier to digest but no large, definitive trials to confirm this.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who report being intolerant to cow milk but not to goat milk (one group) or tolerant to both cow milk and goat milk (another group) * Good general health (WHO grade = 0) * Affiliated with a social security scheme * Free, informed, and express consent, in accordance with the public health code: 'No research mentioned in 2° of Article L. 1121-1 can be conducted on a person without their free, informed, and express consent. Exclusion Criteria: * Individuals under guardianship or curatorship * Individuals under legal protection * Any known food allergies * Anemia: hemoglobin levels below 13 g/dL for men and 12 g/dL for women * Pregnant women or those likely to be (based on a positive urine pregnancy test at the time of inclusion) * Excessive alcohol consumption (\>2 drinks/day). Harmful alcohol consumption is assessed by the investigator at the time of inclusion. * Hypertension, diabetes, digestive tract diseases (except for irritable bowel syndrome, IBS), liver or kidney diseases, severe heart disease. The presence of these conditions will be assessed by the investigator based on usual clinical criteria and the volunteers' declarations during inclusion. Hypertension: Significant arterial hypertension as determined by the investigator or systolic blood pressure greater than or equal to 140 mmHg and/or diastolic blood pressure greater than or equal to 90 mmHg on the day of inclusion. Diabetes: Type 1 or Type 2 diabetes or any fasting blood glucose level \> 1.25 g/l. Digestive tract disease: Gastrointestinal disorders deemed by the investigator as clinically significant (bleeding, vomiting, constipation/diarrhea grade \>1), any inflammatory bowel disease, acute gastroenteritis in the month preceding the intervention. Liver disease: Any significant liver disorder as determined by the investigator or any AST/ALT \> 2.5 times the upper normal limit. * Elite athletes (\> 8 hours per week) * Blood donation in the 3 months preceding the start of the study * Participation in a clinical study in the 3 months preceding the study * Lack of free, informed, and express consent
Where this trial is running
Bobigny
- Hôpital Avicenne, 125 rue de Stalingrad — Bobigny, France (Recruiting)
Study contacts
- Study coordinator: Saviard
- Email: tanguy.saviard@agroparistech.fr
- Phone: +33631312326
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.