Goat milk vs cow milk digestive tolerance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind crossover study compares digestive symptoms and the post-meal handling of nutrients after drinking labeled goat milk versus cow milk. Two groups of adults (those reporting intolerance to cow's milk but not goat's milk, and those tolerant to both) each consume both milks in masked meals separated by at least one month. Stable isotope labeling of the milks is used to track postprandial nutrient kinetics while participants report digestive discomfort during the test period. The design aims to link symptom differences with measurable differences in digestion and nutrient absorption.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals who report being intolerant to cow milk but not to goat milk (one group) or tolerant to both cow milk and goat milk (another group)
* Good general health (WHO grade = 0)
* Affiliated with a social security scheme
* Free, informed, and express consent, in accordance with the public health code: 'No research mentioned in 2° of Article L. 1121-1 can be conducted on a person without their free, informed, and express consent.

Exclusion Criteria:

* Individuals under guardianship or curatorship
* Individuals under legal protection
* Any known food allergies
* Anemia: hemoglobin levels below 13 g/dL for men and 12 g/dL for women
* Pregnant women or those likely to be (based on a positive urine pregnancy test at the time of inclusion)
* Excessive alcohol consumption (\>2 drinks/day). Harmful alcohol consumption is assessed by the investigator at the time of inclusion.
* Hypertension, diabetes, digestive tract diseases (except for irritable bowel syndrome, IBS), liver or kidney diseases, severe heart disease. The presence of these conditions will be assessed by the investigator based on usual clinical criteria and the volunteers' declarations during inclusion. Hypertension: Significant arterial hypertension as determined by the investigator or systolic blood pressure greater than or equal to 140 mmHg and/or diastolic blood pressure greater than or equal to 90 mmHg on the day of inclusion. Diabetes: Type 1 or Type 2 diabetes or any fasting blood glucose level \> 1.25 g/l. Digestive tract disease: Gastrointestinal disorders deemed by the investigator as clinically significant (bleeding, vomiting, constipation/diarrhea grade \>1), any inflammatory bowel disease, acute gastroenteritis in the month preceding the intervention. Liver disease: Any significant liver disorder as determined by the investigator or any AST/ALT \> 2.5 times the upper normal limit.
* Elite athletes (\> 8 hours per week)
* Blood donation in the 3 months preceding the start of the study
* Participation in a clinical study in the 3 months preceding the study
* Lack of free, informed, and express consent

Where it's running

• Hôpital Avicenne, 125 rue de Stalingrad
  Bobigny, France Recruiting

Study contacts

• Study coordinator: Saviard
• Email: tanguy.saviard@agroparistech.fr
• Phone: +33631312326

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.