GLP-1 therapy after bariatric surgery in Chinese patients with obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates the safety and effectiveness of combining bariatric surgery with adjuvant GLP-1 receptor agonist therapy in Chinese patients with obesity. Participants undergo initial laparoscopic sleeve gastrectomy and are assigned to one of four groups receiving either Semaglutide, Mazdutide, Tirzepatide, or no GLP-1RA after surgery. The trial aims to determine if combination therapy yields greater and more durable weight loss and metabolic improvements compared with surgery alone. Eligible adults aged 18 to 60 with BMI ≥30 kg/m² and metabolic comorbidities may participate, excluding those with recent GLP-1RA exposure, prior bariatric surgery, or significant uncontrolled comorbidities. Primary outcomes typically include weight change and safety measures, with secondary assessments of metabolic parameters and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients undergoing initial laparoscopic sleeve gastrectomy (LSG).
2. obesity:BMI ≥30 kg/m².
3. Metabolic comorbidities: Diagnosis of metabolic syndrome or type 2 diabetes mellitus (T2DM) meeting standard criteria.
4. Age range: 18-60 years (inclusive).
5. Informed consent: Willing participation with documented consent.

Exclusion Criteria:

1. Recent GLP-1RA use: Treatment with GLP-1 receptor agonists within 6 months preoperatively.
2. Prior bariatric surgery: History of any metabolic/bariatric surgical procedure.
3. Postoperative complications: Requiring reoperation for severe complications (e.g., hemorrhage, anastomotic leak).
4. Non-indicated candidates: Patients not meeting standard bariatric surgery indications.
5. Significant comorbidities:

5.1Advanced hepatic/renal dysfunction (Child-Pugh C or eGFR \<30 mL/min/1.73m²). 5.2Active malignancy (except non-melanoma skin cancers). 5.3Autoimmune disorders requiring immunosuppression. 5.4Uncontrolled psychiatric conditions (e.g., active psychosis, severe depression).

Where it's running

• China-Japan Friendship Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Yishan Huang, Ph.D
• Email: yuanwen0920@163.com
• Phone: +8618612256920

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.