GLOW Plan: Predicting and Preventing Gestational Diabetes with Lifestyle Support and Glucose Monitoring
Official title: A Multicenter Prospective Cohort Study to Identify Risk Factors and Develop a Diagnostic Prediction Model for Gestational Diabetes Mellitus, and to Evaluate the Effectiveness of Multidisciplinary Precision Health Interventions (GLOW Plan)
Run by The First Affiliated Hospital with Nanjing Medical University · NCT07263412 · Data updated 2026-11-12
This project will test whether combining continuous glucose monitoring, regular self-monitoring, and personalized lifestyle support can help predict and reduce gestational diabetes in pregnant people aged 18–40 who receive care at the participating hospital.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 1000 (estimated) |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing) |
| Status | Recruiting |
| Started | February 25, 2025 |
| Main results expected | November 2026 |
| Study ends | November 2028 |
| Registry record updated | December 4, 2025 |
| Trial ID | NCT07263412 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnant people aged 18–40 with pre-pregnancy BMI between 18.5 and 28 who receive prenatal care and plan to deliver at the participating hospital, and who can read consent forms and use CGM/SMBG, are ideal candidates.
✕Probably not a fit
People with multiple pregnancies, pre-existing diabetes, poorly controlled chronic hypertension, severe organ disease or infection, recent use of glucose-altering drugs, significant psychiatric illness, or who cannot comply with CGM/SMBG are unlikely to benefit from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter prospective observational cohort will enroll pregnant people who meet the age and pre-pregnancy BMI criteria and follow them through pregnancy and delivery. Participants will undergo continuous glucose monitoring (CGM), routine self-monitoring of blood glucose (SMBG), or standard care while receiving multidisciplinary precision lifestyle support according to the GLOW Plan as implemented at each site. Investigators will collect clinical, metabolic, and behavioral data to identify risk factors and to develop a diagnostic prediction model for gestational diabetes mellitus (GDM). Outcomes include GDM diagnosis, maternal glycemic patterns, and birth outcomes compared across monitoring and management approaches.
Why it matters
Potential benefit: If successful, this could help identify people at high risk for GDM earlier and provide personalized glucose monitoring and lifestyle support to reduce pregnancy complications.
How similar studies have gone: Previous studies using CGM and personalized lifestyle support have shown promise for improving glycemic control in pregnancy and some diagnostic models for GDM exist, though results and accuracy have varied across settings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: All must be met 1. Aged 18-40 years; 2. Pre-pregnancy BMI: 18.5 kg/m² \< BMI \< 28 kg/m²; 3. Able to read, understand and sign the informed consent form; 4. Receive prenatal care and deliver in the study hospital. Exclusion Criteria: Any one met leads to exclusion 1. Twin or multiple pregnancies; 2. Pre-gestational diabetes mellitus (PGDM), including new-onset diabetes during pregnancy; 3. Poorly controlled pre-pregnancy chronic hypertension (BP ≥140/90 mmHg); 4. Complicated with severe liver/kidney diseases; 5. Current/recent use of drugs affecting glucose metabolism; 6. Mental illness or severe psychological disorders; 7. Complicated with severe infection; 8. Poor compliance or refusal to use CGM/SMBG.
Where it's running
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Jiangsu women and children health hospital
Nanjing, China Recruiting
Study contacts
- Study coordinator: Wu
- Email: 2543481029@stu.njmu.edu.cn
- Phone: 8618155394955
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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ASPIRE: Predicting Pregnancy Complications Using Blood and Eye Imaging
This study tests whether blood and eye imaging biomarkers can predict conditions like preeclampsia, fetal growth restriction, and gestational diabetes in first-time pregnant people carrying one baby.
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Evaluating Lactobacillus Rhamnosus LRa05 for Gestational Diabetes
This study is testing whether a probiotic called Lactobacillus rhamnosus LRa05 can help women with gestational diabetes improve their blood sugar and overall health while they receive standard treatment.
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Studying how a mother's glucose control during pregnancy affects her baby's glucose levels after birth
This study looks at how well a mother's blood sugar is controlled during pregnancy to see if it affects her baby's blood sugar levels after birth.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.