Glomerulonephritis Kidney Transplant Recipient Cohort (China)
Official title: China Glomerulonephritis Kidney Transplant Recipient Cohort: A Prospective Multicenter Observational Study
Run by AstraZeneca · NCT07783737 · Data updated 2026-11-12
This study will follow adults with glomerulonephritis who are scheduled for kidney transplant in China to see how GN recurs after transplant and how the primary disease progresses over 3 years.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | AstraZeneca Industry-sponsored |
| Locations | 9 sites (Beijing, Beijing Municipality and 8 other locations) |
| Status | Recruiting |
| Started | October 1, 2026 |
| Main results expected | August 29, 2030 |
| Study ends | August 29, 2030 |
| Registry record updated | October 21, 2026 |
| Trial ID | NCT07783737 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with primary glomerulonephritis scheduled for kidney transplantation.
✕Probably not a fit
Patients who do not have GN recurrence or whose management is standard across sites may not see direct benefits from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter, prospective observational study enrolling about 300 adults with confirmed glomerulonephritis before kidney transplantation. Participants will be followed from screening through kidney transplantation and for 3 years afterward, with visits every 3 months in year 1 and every 6 months in years 2–3 (eight total visits across sites in Beijing, Guangzhou, and Nanning). The study will collect data on GN recurrence, post-transplant outcomes, and treatment of the primary disease to inform future research, drug development, and translational work. No interventions are assigned; the study observes real-world clinical practice across 10 centers in China.
Why it matters
Potential benefit: If successful, findings could clarify GN recurrence patterns after transplantation and help optimize post-transplant management for GN patients.
How similar studies have gone: Prior observational work in transplant populations has shown value in understanding disease recurrence and outcomes, though this specific GN pre-transplant cohort is relatively novel in China.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Diagnosed with primary GN based on clinical guidelines and/or expert consensus * Successfully matching completed and confirmed to be scheduled for kidney transplantation. Exclusion Criteria: * History of organ transplantation or planned multiple organ transplantation. * Complicated with malignancy. * Failure to undergo kidney transplantation for any reason. * Unable to provide written informed consent form (ICF).
Where it's running
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Research Site
Nanning, Guangxi, China Recruiting -
Research Site
Beijing, Beijing Municipality, China Not yet recruiting -
Research Site
Guangzhou, Guangdong, China Not yet recruiting -
Research Site
Zhengzhou, Henan, China Not yet recruiting -
Research Site
Wuhan, Hubei, China Not yet recruiting -
Research Site
Yantai, Shandong, China Not yet recruiting
Show 3 more locations
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Research Site
Shanghai, Shanghai Municipality, China Terminated -
Research Site
Taiyuan, Shanxi, China Not yet recruiting -
Research Cite
Tianjin, Tianjin Municipality, China Not yet recruiting
Study contacts
- Study coordinator: AstraZeneca Clinical Study Information Center
- Email: information.center@astrazeneca.com
- Phone: 1-877-240-9479
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.