Global analysis of cardiovascular risk factors and their impact on health
Official title: Predicting Cardiovascular Risk by Geographical Region and Sex Using Classical Cardiovascular Risk Factors
Run by Universitätsklinikum Hamburg-Eppendorf · NCT05466825 · Data updated 2026-11-12
This study looks at how common heart disease risk factors like weight, blood pressure, and smoking affect people's heart health and overall survival to help create better prevention strategies worldwide.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000000 (estimated) |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf Academic / other |
| Locations | 1 site (Hamburg, Free and Hanseatic City of Hamburg) |
| Status | Recruiting |
| Started | September 20, 2019 |
| Main results expected | December 31, 2027 |
| Study ends | June 30, 2028 |
| Registry record updated | February 27, 2026 |
| Trial ID | NCT05466825 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 18 and older with available data on classical cardiovascular risk factors.
✕Probably not a fit
Patients with a history of cardiovascular disease at baseline will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The Global Cardiovascular Risk Consortium (GCVRC) is an international collaboration that aggregates individual-level data from over 2 million participants across 133 cohorts in 39 countries. This observational study focuses on classical cardiovascular risk factors such as body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, smoking, and diabetes, examining their effects on cardiovascular disease and all-cause mortality. By analyzing this extensive data, the GCVRC aims to develop region-specific strategies for cardiovascular disease prevention and treatment, enhancing global cardiovascular health outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing cardiovascular disease and reducing mortality worldwide.
How similar studies have gone: Previous studies have shown success in understanding cardiovascular risk factors, making this approach a continuation of established research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Population-based individual-level data with available information on the classical cardiovascular risk factors including body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes, as well as the outcomes of interest. Exclusion Criteria: * Participants with age below 18 years * No information on the outcome of interest * No information on the exposure of interest (CVD risk factors) * History of CVD at baseline
Where it's running
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University Medical Center Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany Recruiting
Study contacts
- Study coordinator: Prof. Dr. med. Stefan Blankenberg
- Email: s.blankenberg@uke.de
- Phone: +49 (0)40 741056800
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.