Clinical trial Recruiting at 1 site Observational Ages 18 and up

Global analysis of cardiovascular risk factors and their impact on health

Official title: Predicting Cardiovascular Risk by Geographical Region and Sex Using Classical Cardiovascular Risk Factors

Run by Universitätsklinikum Hamburg-Eppendorf · NCT05466825 · Data updated 2026-11-12

This study looks at how common heart disease risk factors like weight, blood pressure, and smoking affect people's heart health and overall survival to help create better prevention strategies worldwide.

More Cardiovascular Disease trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment3000000 (estimated)
SponsorUniversitätsklinikum Hamburg-Eppendorf
Academic / other
Locations1 site (Hamburg, Free and Hanseatic City of Hamburg)
StatusRecruiting
StartedSeptember 20, 2019
Main results expectedDecember 31, 2027
Study endsJune 30, 2028
Registry record updatedFebruary 27, 2026
Trial IDNCT05466825 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals aged 18 and older with available data on classical cardiovascular risk factors.

Probably not a fit

Patients with a history of cardiovascular disease at baseline will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Global Cardiovascular Risk Consortium (GCVRC) is an international collaboration that aggregates individual-level data from over 2 million participants across 133 cohorts in 39 countries. This observational study focuses on classical cardiovascular risk factors such as body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, smoking, and diabetes, examining their effects on cardiovascular disease and all-cause mortality. By analyzing this extensive data, the GCVRC aims to develop region-specific strategies for cardiovascular disease prevention and treatment, enhancing global cardiovascular health outcomes.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for preventing cardiovascular disease and reducing mortality worldwide.

How similar studies have gone: Previous studies have shown success in understanding cardiovascular risk factors, making this approach a continuation of established research.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Population-based individual-level data with available information on the classical cardiovascular risk factors including body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes, as well as the outcomes of interest.

Exclusion Criteria:

* Participants with age below 18 years
* No information on the outcome of interest
* No information on the exposure of interest (CVD risk factors)
* History of CVD at baseline

Where it's running

  • University Medical Center Hamburg-Eppendorf
    Hamburg, Free and Hanseatic City of Hamburg, Germany
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.