GFH009 combined with Zanubrutinib for treating relapsed DLBCL

A Phase Ib/II, Multicenter, Open-label, Single-arm Study to Assess the Safety and Efficacy of GFH009 in Combination With Zanubrutinib in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

This study is testing if a new treatment combining GFH009 and Zanubrutinib can help people with relapsed or hard-to-treat diffuse large B-cell lymphoma feel better.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 51 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Genfleet Therapeutics (Shanghai) Inc. (Industry-sponsored)
• Drugs / interventions: Rituximab, CAR-T, chemotherapy, immunotherapy, radiation, prednisone, Zanubrutinib
• Locations: 2 sites (Nanning and 1 other locations)
• Trial ID: NCT06375733 on ClinicalTrials.gov

What this trial studies

This multicenter, open-label phase Ib/II study evaluates the safety and efficacy of GFH009 in combination with Zanubrutinib in patients suffering from relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Participants must have experienced relapse or refractory disease after receiving 2 to 4 systemic treatment regimens, including anthracyclines and Rituximab. The study aims to determine how well this combination therapy works in managing the disease and improving patient outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with relapsed or refractory DLBCL who have undergone multiple prior treatments.

Not a fit: Patients who are suitable for stem cell transplantation or have not received prior systemic treatments may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with difficult-to-treat DLBCL.

How similar studies have performed: Other studies have shown promise with similar combination therapies in treating DLBCL, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Age ≥ 18 years old.
2. Relapsed or refractory diffuse large B-cell lymphoma (DLBCL), including: DLBCL, not specified (NOS), T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL), high-grade B-cell lymphoma, or large B-cell lymphoma transformed from indolent B-cell lymphoma (including but not limited to Richter syndrome, transformed follicular lymphoma, transformed MZL) (2016 WHO classification).
3. Relapse or refractory after receiving 2\~4 systemic treatment regimens, at least one of which contains anthracyclines and Rituximab.
4. Must have a measurable lesion.
5. The patient is not suitable to receive stem cell transplantation judged by the investigator.
6. The Eastern Cooperative Oncology Group (ECOG) performance status score (PS) is 0\~2.
7. Have adequate organ function, including:

   i. Hematopoietic function: absolute neutrophil count (ANC) ≥1.0×109/L, platelet count (PLT) ≥75×109/L and hemoglobin (Hgb) ≥ 80 g/L.

ii. Liver function: total bilirubin ≤ 1.5 × upper limit of normal (ULN), Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × ULN.

iii. Renal function: Serum creatinine (Cr) ≤ 1.5 × ULN, or serum creatinine clearance ≥ 50 mL/min when Cr \> 1.5× ULN.

iv. Coagulation function: International normalized ratio (INR) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN.

Exclusion Criteria:

1. Primary or secondary central nervous system (CNS) lymphoma.
2. Received chemotherapy, targeted therapy, endocrine therapy, immunotherapy, Chinese patent medicine with anti-tumor effect and other investigational drugs or device therapy within 28 days or 5 half-lives (whichever is shorter), or received therapeutic or palliative radiotherapy within 14 days, or received CAR-T therapy within 12 weeks prior to the administration of the study drugs.
3. Patients with primary resistance to CDK9 or BTK inhibitors.
4. Has a history of organ transplantation or allogeneic stem cell transplantation. Patients who have undergone autologous stem cell transplantation within 6 months.
5. Other malignancies within 2 years prior to study entry, excluding appropriately treated carcinoma in situ of the cervix, focal squamous cell carcinoma of the skin, basal cell carcinoma, prostate cancer not requiring treatment, ductal carcinoma in situ of the breast, and superficial non-muscle-invasive urothelial carcinoma.
6. Have significant diseases of the cardiovascular system or significant acute or chronic infection. History of stroke or intracranial hemorrhage within 6 months prior to enrollment. Presence of significant gastrointestinal disorders. Current clinically significant interstitial lung disease, radiation pneumonitis, or drug-associated pneumonia requiring treatment. Accompanied by other poorly controlled systemic diseases, such as hypertension, diabetes mellitus, etc.
7. Has a history of bleeding disorder or a history of spontaneous bleeding requiring blood transfusion or other medical intervention. Active bleeding within 2 months prior to the first dose.
8. Surgical procedures (excluding needle biopsies) that may affect the administration or study evaluation of this study within 28 days prior to the first dose.
9. Patients who have been treated with prednisone (or equivalent doses of glucocorticoids) at \>20 mg/day for anti-tumor purposes within 7 days, or who require long-term use of glucocorticoids for non-anti-tumor therapy.
10. Ongoing medical treatment with a potent inhibitor or inducer of CYP3A is required.

Where this trial is running

Nanning and 1 other locations

• Guangxi Medical University Cancer Hospital&Guangxi Cancer Institute — Nanning, China (Recruiting)
• Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital — Zhengzhou, China (Recruiting)

Study contacts

• Principal investigator: Keshu Zhou, MD — Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital
• Study coordinator: Yolanda Zeng

Conditions Large B-cell Lymphoma; relapsed or refractory diffuse large B-cell lymphoma