Genetic testing to improve pregnancy rates in women with repeated implantation failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of Preimplantation Genetic Testing for Aneuploidies (PGT-A) in women experiencing recurrent implantation failure. It aims to determine if PGT-A can enhance the ongoing pregnancy rate per transferred embryo and reduce the time to pregnancy and miscarriage rates. The study involves comparing outcomes between patients receiving PGT-A and those receiving standard care. Women with a history of multiple failed embryo transfers will be recruited for this intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women with recurrent implantation failure (previous transfer of least 4 good quality embryos in at least 3 fresh or frozen cycles)
* BMI \< 35
* Normal hysteroscopy

Exclusion Criteria:

* thin endometrium in previous cycles (\<6mm), endometriosis ASRM score III-IV, premature ovarian failure (POF, Bologna criteria), abnormal karyotype, donor oocytes or embryos, PGT-M

Where it's running

• UZ Leuven
  Leuven, Belgium Recruiting

Study contacts

• Study coordinator: Myriam Welkenhuysen
• Email: myriam.welkenhuysen@uzleuven.be
• Phone: +3216343544

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing timing of embryo transfer in women with recurrent implantation failure

  This study is testing if timing frozen embryo transfers based on a special test can help women with repeated implantation failures get pregnant more successfully than using the usual timing methods.

  Recruiting The University of Hong Kong · Hong Kong · NCT06762626

• Using bone marrow stem cells to treat abnormal endometrium conditions

  This study is testing if using a special treatment to help bone marrow stem cells can improve conditions like Asherman's Syndrome and help women get pregnant better than standard care.

  Recruiting Early Phase 1 Yale University · Orange, Connecticut · NCT05343572

• Mannose-binding lectin levels and repeated pregnancy or implantation failure

  This project will test whether low blood levels of mannose-binding lectin are linked to repeated pregnancy loss, repeated failed embryo transfers after IVF/ICSI/FET, or other unexplained infertility in people with three consecutive pregnancy failures.

  Recruiting Aalborg University Hospital · Aarhus · NCT05169541

• Using Certolizumab to Help Women with Recurrent Implantation Failure

  This study is testing if a medication called Certolizumab can help women who have trouble getting pregnant after transferring good-quality embryos by improving their chances of successful implantation.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT05930613

• Using Platelet-rich Plasma to Improve Female Fertility

  This study is testing whether injections of platelet-rich plasma can help improve fertility in women dealing with issues like poor ovarian response and repeated implantation failure.

  Recruiting The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT06645379

• Acupuncture to improve IVF pregnancy chances for women with repeated implantation failure

  This study will test whether adding real acupuncture to IVF helps women with repeated implantation failure (two or more failed good-quality embryo transfers) get pregnant compared with sham acupuncture or IVF alone.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT04533295

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.