Genetic testing to improve pregnancy rates in women with repeated implantation failure
Preimplantion Genetic Testing for Aneuploidies (PGT-A) in Patients With Recurrent Implantation Failure: a Pilot RCT
This study tests if a genetic test for embryos can help women who have had multiple failed pregnancies get pregnant more easily and have healthier pregnancies.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT03900780 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of Preimplantation Genetic Testing for Aneuploidies (PGT-A) in women experiencing recurrent implantation failure. It aims to determine if PGT-A can enhance the ongoing pregnancy rate per transferred embryo and reduce the time to pregnancy and miscarriage rates. The study involves comparing outcomes between patients receiving PGT-A and those receiving standard care. Women with a history of multiple failed embryo transfers will be recruited for this intervention.
Who should consider this trial
Good fit: Ideal candidates are women who have experienced recurrent implantation failure, defined as having transferred at least four good quality embryos across three or more cycles.
Not a fit: Patients with conditions such as thin endometrium, severe endometriosis, or those using donor oocytes or embryos may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pregnancy outcomes for women with recurrent implantation failure.
How similar studies have performed: Previous studies have shown promising results with PGT-A in improving pregnancy rates, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women with recurrent implantation failure (previous transfer of least 4 good quality embryos in at least 3 fresh or frozen cycles) * BMI \< 35 * Normal hysteroscopy Exclusion Criteria: * thin endometrium in previous cycles (\<6mm), endometriosis ASRM score III-IV, premature ovarian failure (POF, Bologna criteria), abnormal karyotype, donor oocytes or embryos, PGT-M
Where this trial is running
Leuven
- UZ Leuven — Leuven, Belgium (Recruiting)
Study contacts
- Study coordinator: Myriam Welkenhuysen
- Email: myriam.welkenhuysen@uzleuven.be
- Phone: +3216343544
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.