Genetic study of Type 2 Diabetes in West Africans

Genetics of Type 2 Diabetes in Diverse Populations

This study is trying to find out how genetics affects Type 2 Diabetes and its complications in people from the Yoruba population in Nigeria.

Quick facts

• Study type: Observational
• Enrollment: 10000 (estimated)
• Ages: 18 Years to 120 Years
• Sex: All
• Sponsor: National Institutes of Health Clinical Center (CC) (nih)
• Locations: 5 sites (Accra and 4 other locations)
• Trial ID: NCT00837122 on ClinicalTrials.gov

What this trial studies

This study aims to investigate the genetic factors contributing to Type 2 Diabetes (T2D) and its complications among the Yoruba population in Nigeria. It will enroll 300 individuals with T2D and 300 matched controls to conduct a genome-wide association study (GWAS) and identify genetic variants associated with the disease. The research will also explore gene-environment interactions and develop a genetic epidemiological resource for further studies. Additionally, the study will provide insights into the prevalence of cardiometabolic traits in the population.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged over 25 years, either diagnosed with Type 2 Diabetes or without a diabetes diagnosis.

Not a fit: Patients with diabetes of other etiologies, such as Type 1 Diabetes, or those under 25 years old may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for Type 2 Diabetes and related conditions in African populations.

How similar studies have performed: Other studies have shown success in identifying genetic factors related to diabetes in diverse populations, making this approach promising yet still novel in the context of West African populations.

Eligibility criteria

* INCLUSION CRITERIA:

As our primary interest is in T2D, it is important to exclude individuals who may have diabetes of another etiology. Elevated blood glucose in individuals 25 years old or younger is unlikely (in West Africa) to result from T2D and may reflect Type 1 Diabetes. Therefore, only individuals older than 25 years will be included in this study.

We are seeking to enroll persons without T2D or with previously or newly diagnosed T2D. Previously diagnosed cases will be determined by self-report of being treated with oral medication or insulin. Newly diagnosed cases will be determined by fasting blood glucose value \>= 126 mg/dl on more than one occasion. Individuals who have elevated blood glucose during their initial reading will be asked to return to the study site for a second test. If this test also has a fasting blood glucose value \>= 126 mg/dl, then they will be considered a new case. The control group will be individuals with no report of T2D diagnosis and fasting plasma glucose (FPG)\< 126 mg/dl.

Only unrelated individuals will be included in this phase of the study to avoid confounding genetic association studies by relatedness in the study population.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

* Incarceration.
* Lack capacity to consent to research participation.
* Pregnancy.

Where this trial is running

Accra and 4 other locations

• University of Ghana — Accra, Ghana (COMPLETED)
• University of Science and Tech — Kumasi, Ghana (COMPLETED)
• University of Nigeria — Enugu, Nigeria (COMPLETED)
• University of Ibadan — Ibadan, Nigeria (RECRUITING)
• University of Lagos — Lagos, Nigeria (COMPLETED)

Study contacts

• Principal investigator: Charles N Rotimi, M.D. — National Human Genome Research Institute (NHGRI)
• Study coordinator: Shirley T Freeman

Conditions: Hypertension, Diabetes, African, Natural History