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Genetic identification of obesity in children

Whole Genetic Approach in Early Genetic Identification of Obesity (WEGIO)

Observational Rolfs Consulting und Verwaltungs-GmbH (RCV) · NCT06239064

This study is testing how common Bardet-Biedl Syndrome is in children and adults with certain obesity symptoms by looking at their genes and comparing the results with people from other countries.

Quick facts

Study typeObservational
Enrollment1000 (estimated)
Ages2 Years and up
SexAll
SponsorRolfs Consulting und Verwaltungs-GmbH (RCV) Research network
Locations37 sites (Aachen and 36 other locations)
Trial IDNCT06239064 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate the prevalence of Bardet-Biedl Syndrome (BBS) in a population at risk for syndromic or monogenic obesity. It employs a multicenter epidemiological approach, involving genetic sequencing of approximately 1000 participants, followed by detailed clinical documentation for about 40 individuals. The study also seeks to explore genotype-phenotype correlations and assess the distribution of genotypes in Germany compared to other countries. Participants include children and adults with specific obesity-related symptoms and genetic predispositions.

Who should consider this trial

Good fit: Ideal candidates include individuals aged 2 years and older with a history of obesity and symptoms associated with Bardet-Biedl Syndrome.

Not a fit: Patients who do not meet the inclusion criteria or do not exhibit symptoms related to genetic obesity may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to earlier genetic identification and better management of obesity-related conditions in at-risk populations.

How similar studies have performed: While this approach is novel in its specific focus on early genetic identification of obesity, similar studies have shown promise in understanding genetic contributions to obesity.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion criteria:

* Informed consent is obtained from the participant/parent/legal guardian
* The participant is 2 years of age or older

For a participant between 2 and 18 years of age:

* The participant has and had a body weight more than 97th percentile before the age of 6
* The participant has one or more of the following symptoms:

rod/cone dystrophy, renal abnormalities, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, hypogonadism

For a participant who is 18 years of age or older:

* The participant has BMI ≥ 30 kg/m2
* The participant had a body weight more than 97th percentile before the age of 6 years
* The participant has rod/cone dystrophy
* The participant is 2 or more years of age, is clinically diagnosed with Bardet-Biedl-Syndrome (BBS) or is a sibling of an individual diagnosed with BBS via the WEGIO study

Exclusion criteria:

- Not fulfilling the inclusion criteria

Where this trial is running

Aachen and 36 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Obesity, ChildhoodHyperphagiaRetinopathySyndactylyPolydactylyCognitive ImpairmentBardet-Biedl SyndromePOMC Deficiency
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.