Genetic-guided psychotropic medication choices for adults in Manitoba
Official title: Pharmacogenomics-Supported Psychotropic Prescribing Trial (PGx-SUPPORT): A Pilot Implementation Study in Manitoba
Run by University of Manitoba · NCT06929533 · Data updated 2026-11-12
This project will test whether using a patient's genetics to guide psychotropic medication choices helps adults in Manitoba who are starting or changing psychiatric medicines.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Manitoba Academic / other |
| Locations | 2 sites (Winnipeg, Manitoba and 1 other locations) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2030 |
| Registry record updated | September 8, 2025 |
| Trial ID | NCT06929533 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older in Manitoba who are starting, changing, adjusting, or augmenting psychotropic medications and who are referred by a treating clinician, can provide a saliva sample, and have a personal health identification number.
✕Probably not a fit
Patients who already have pharmacogenetic results, who are unwilling to provide a saliva sample, who lack a personal health identification number, or who have had liver or bone marrow transplants are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional project offers pharmacogenetic (PGx) testing using saliva samples to adults seeking mental health care in Manitoba and tracks whether test results influence prescribing. Feasibility will be measured across acceptability (patient and clinician satisfaction), practicality (turnaround time), implementation (clinicians' use of results), and demand (referrals and intent to use). Secondary outcomes include changes in global functioning and symptom severity using measures such as CGI, BPRS, PHQ-9, and GAD-7. The work is delivered through Shared Health facilities and the University of Manitoba with local clinician referrals.
Why it matters
Potential benefit: If successful, PGx-guided prescribing could speed finding the right medication, reduce adverse reactions, and improve symptom control.
How similar studies have gone: Some prior pharmacogenetic-guided prescribing studies have shown modest improvements in medication selection and fewer adverse reactions, but results have been mixed and local feasibility in Manitoba has not been tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years or older * The initiation, change, dose adjustment, or augmentation of psychotropic medication(s) is indicated * The treating clinician thinks PGx testing can benefit and refers the patient to the study Exclusion Criteria: * Unwillingness to donate saliva samples for genetic analysis * History of liver or bone marrow (hematopoietic cell) transplantation * PGx testing results are already available * No personal health identification number (PHIN) is available
Where it's running
-
University of Manitoba College of Pharmacy
Winnipeg, Manitoba, Canada Recruiting -
Shared Health Facilities
Winnipeg, Manitoba, Canada Not yet recruiting
Study contacts
- Principal investigator: Abdullah Al Maruf, PhD, M.Pharm., B.Pharm — University of Manitoba
- Study coordinator: Abdullah Al Maruf, BPharm, MPharm, PhD
- Email: abdullah.maruf@umanitoba.ca
- Phone: 204-318-2575
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.