Genetic analysis of male infertility due to obstructive azoospermia
Genetic Study of Obstructive Azoospermia
This study is testing whether certain genetic changes in men with obstructive azoospermia can help us understand their infertility and improve future treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Male |
| Sponsor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT05631509 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on men experiencing obstructive azoospermia, a condition where no sperm is found in the semen due to blockages. It aims to identify genetic mutations in the CFTR and ADGRG2 genes that may contribute to this condition, particularly in cases of congenital absence of the vas deferens. By conducting genetic testing, the study seeks to inform assisted reproductive technologies and prevent the transmission of infertility-related mutations to future generations. The study will involve multiple semen tests and genetic evaluations to establish a clearer understanding of the genetic factors involved.
Who should consider this trial
Good fit: Ideal candidates for this study are men diagnosed with obstructive azoospermia who meet specific genetic and clinical criteria.
Not a fit: Patients with abnormalities in the urinary system or those who have undergone certain surgical procedures related to the reproductive system may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify genetic risks in male infertility, allowing for informed reproductive choices and potentially reducing the incidence of inherited infertility in offspring.
How similar studies have performed: Other studies have shown success in identifying genetic causes of male infertility, making this approach both relevant and promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * No sperm was found after centrifugation for 15min for two or more semen tests, and the interval between two tests was at least 2 weeks. * Blood FSH is normal; * Hematostatin b is normal; * Chromosome karyotype is normal or polymorphic; * Y chromosome microdeletion did not show the deletion:(main locus); * Biochemical fructose of seminal plasma : less than the normal value; * PH of semen \<7.2; * Transscrotal or transrectal ultrasound: normal testicular size(as measured by B ultrasound), presence or dysplasia of vas deferens and epididymis; Exclusion Criteria: * B ultrasound of urinary system suggested abnormal development; * Transscrotal or Transrectal ultrasound indicated absence of vas deferens or epididymis or seminal vesicle; * Physical examination showed the following abnormalities: cryptorchidism, tenderness of testis and epididymis; * The following medical history: genitourinary tract trauma or surgical history; orchitis; epididymitis; Seminal vesicle disease; mumps; * Laboratory examination: red and white blood cell elevation of semen routine
Where this trial is running
Guangzhou, Guangdong
- 107 Yan Jiang Xi Road — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Ping Yuan, PhD
- Email: kekeyp1983@163.com
- Phone: 86-20-81332230
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.