Genetic analysis of keloids
Official title: Identification of Genetic Variants That Contribute to Keloid Formation in Families and Isolated Cases.
Run by UConn Health · NCT01619553 · Data updated 2026-11-12
This study is trying to find out if certain genes play a role in how keloids form and grow, by looking at saliva samples and scar tissue from people with these scars.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 7000 (estimated) |
| Sponsor | UConn Health Academic / other |
| Locations | 1 site (Farmington, Connecticut) |
| Status | Recruiting |
| Started | April 2009 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | April 15, 2026 |
| Trial ID | NCT01619553 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with keloids and unaffected family members of keloid patients.
✕Probably not a fit
Patients without keloids or those not related to a keloid-affected family may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to identify the genetic factors contributing to the development of keloids, which are abnormal scars that grow beyond the original wound site. Participants will provide saliva samples and information about their keloids, and if they undergo surgery, scar tissue may also be collected for analysis. The research will focus on isolating DNA and performing genetic analyses to uncover variations that may influence keloid formation and severity. The ultimate goal is to enhance understanding of the genetic basis of keloids and their behavior.
Why it matters
Potential benefit: If successful, this study could lead to better prevention and treatment strategies for keloids.
How similar studies have gone: While genetic studies on keloids are limited, similar approaches in other genetic conditions have shown promise in identifying causative factors.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * keloids; * unaffected individuals only if part of a participating keloid family Exclusion Criteria: * no keloids; * unaffected individuals only as part of a participating keloid family
Where it's running
-
University of Connecticut Health Center (UCHC)
Farmington, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Ernst Reichenberger, PhD — UConn Health
- Study coordinator: Ernst Reichenberger, PhD
- Email: reichenberger@uchc.edu
- Phone: 866-512-9897
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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See if 68Ga-RGD PET-CT helps diagnose keloids and track treatment response
This study tests whether 68Ga-RGD PET-CT imaging can help diagnose keloids and gauge how well treatments work for people with keloids.
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Using ritlecitinib to treat keloids and patients undergoing keloid surgery
This study is testing if a new medication called ritlecitinib can help treat keloids in people who have them or are having surgery to remove them.
-
Radiation therapy for treating keloids
This study is testing if radiation therapy can safely help people with stubborn keloids by reducing their size and improving their quality of life.
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Online survey about keloid disorder
This study is trying to gather information from people with keloids about their experiences, family history, and treatments to better understand this condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.