Gene therapy approach for treating hearing loss using human inner ear cells

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the use of adeno-associated virus (AAV) for gene therapy targeting hearing loss and vestibular disorders. It focuses on the viral transduction of human auditory sensory cells collected during surgeries for vestibular schwannoma. The study aims to enhance understanding of how AAV can be utilized in the inner ear, potentially paving the way for future therapeutic applications. Participants will be patients undergoing specific surgical procedures, allowing for the collection of inner ear cells for analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient ≥ 18 years old
* Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient
* Informed consent obtained
* Patients with a french social protection (AME excluded)

Exclusion Criteria:

* Intravestibular or intra-cochlear extension of the tumor
* Pregnant woman
* Patient with administrative control
* Medical contra-indication

Where it's running

• Hôpital de Bicêtre
  Le Kremlin-Bicêtre, Île-de-France Region, France Recruiting
• Hôpital Pitié-Salpétrière
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Ghizlene Lahlou
• Email: ghizlene.lahlou@pasteur.fr
• Phone: 33 1 45688891

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Long-term hearing and speech outcomes after cochlear implants

  This project will see if cochlear implants improve hearing, speech understanding, and quality of life in Mandarin-speaking patients of all ages before and after surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai · NCT07380269

• Comparing domestic and imported hearing aids for age-related hearing loss

  This study is testing whether hearing aids made in the U.S. work better than imported ones for older adults with age-related hearing loss.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06882889

• Gene therapy for hearing loss caused by OTOF gene mutations

  This study is testing a new gene therapy to see if it can help children with hearing loss caused by OTOF gene mutations hear better.

  Recruiting at 2 sites Eye & ENT Hospital of Fudan University · Zhengzhou, Henan and 1 other locations · NCT06722170

• Using robotics and electrocochleography for cochlear implant surgery

  This study is testing if using a robotic system during cochlear implant surgery can help improve outcomes for people with hearing loss.

  Recruiting iotaMotion, Inc. · Iowa City, Iowa · NCT06664710

• Understanding listening effort in cochlear implant users

  This study tests how much effort people with cochlear implants need to understand speech compared to those with normal hearing, using speech tests and measuring pupil size to see how hard they are working to listen.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06516575

• Comparing experiences of over-the-counter and audiologist-fitted hearing aids

  This study looks at how people with mild-to-moderate hearing loss feel about using over-the-counter hearing aids compared to those fitted by an audiologist to see which option works better for their hearing and quality of life.

  Recruiting at 2 sites University of Iowa · Iowa City, Iowa and 1 other locations · NCT06499805

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.