Clinical trial Recruiting at 1 site Observational Ages 40 to 74

Gathering genetic information to improve coronary artery disease risk prediction

Official title: Genetics and Vascular Health Check Study (GENVASC)

Run by University of Leicester · NCT04417387 · Data updated 2026-11-12

This study is testing if using genetic information can help doctors better predict the risk of coronary artery disease in people, especially those who are currently considered at low or medium risk.

More Cardiovascular Diseases trials

Quick facts

Study typeObservational
Ages40 Years to 74 Years
SexAll
Enrollment30000 (estimated)
SponsorUniversity of Leicester
Academic / other
Locations1 site (Leicester)
StatusRecruiting
StartedSeptember 9, 2012
Main results expectedMarch 31, 2027
Study endsMarch 31, 2027
Registry record updatedNovember 30, 2023
Trial IDNCT04417387 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are males and females aged 40 to 74 who are eligible for an NHS Health Check.

Probably not a fit

Patients with a history of preexisting cardiovascular disease or blood borne infections will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Genetics and Vascular Health Check study (GENVASC) aims to determine if genetic information can enhance the prediction of Coronary Artery Disease (CAD) risk. Conducted in collaboration with Clinical Commissioning Groups and Primary Care practices in Leicester, Leicestershire, and Northamptonshire, this observational study seeks to refine current risk categorization methods. By analyzing genetic variants alongside traditional demographic and lifestyle factors, the study hopes to identify individuals at risk more accurately, particularly those in low and medium risk categories who may benefit from targeted prevention strategies.

Why it matters

Potential benefit: If successful, this study could lead to improved risk assessment and prevention strategies for individuals at risk of coronary artery disease.

How similar studies have gone: Other studies have shown promise in using genetic information to improve risk prediction for cardiovascular diseases, making this approach both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male and female patients who are eligible for an NHS Health Check
* Aged between 40 and 74 years of age
* Able to provide informed consent

Exclusion Criteria:

* History of preexisting cardiovascular disease
* History of blood borne infection (such as HIV, Hepatitis B)
* Unable to provide informed consent

Where it's running

  • Primary Care, LLR and Northamptonshire
    Leicester, United Kingdom
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.