Gastric Tube Placement Site and Risk of Ventilator-Associated Pneumonia in Mechanically Ventilated Patients
Official title: Impact of the Choice of Gastric Tube Placement Sites on the Incidence of Ventilator Associated Pneumonia and Other Complications in the Intensive Care Unit
Run by Centre Hospitalier le Mans · NCT05915663 · Data updated 2026-11-12
This study tests whether putting a gastric tube through the mouth (orogastric) or the nose (nasogastric) affects the risk of ventilator-associated pneumonia in adults on mechanical ventilation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2400 (estimated) |
| Sponsor | Centre Hospitalier le Mans Academic / other |
| Locations | 16 sites (Angers and 15 other locations) |
| Status | Recruiting |
| Started | November 7, 2024 |
| Main results expected | April 7, 2027 |
| Study ends | April 7, 2027 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT05915663 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults in intensive care who are intubated, require a gastric tube, and are expected to remain on ventilation for more than 48 hours.
✕Probably not a fit
Patients who do not benefit may include those with contraindications to nasal or oral tube placement or those whose clinical care is not affected by tube route.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In ICU patients who require a gastric tube, practice varies on whether the tube is inserted nasally or orally. The trial compares oral versus nasal placement to see if the site influences the rate of ventilator-associated pneumonia, a serious infection for intubated patients. The study tracks patients who are intubated, ventilated, and need a gastric tube for at least 48 hours, enrolling under appropriate consent rules. The intervention focuses on the route of tube placement and its potential impact on infection risk, with outcomes relevant to ICU stay and treatment burden.
Why it matters
Potential benefit: If successful, the approach could reduce ventilator-associated pneumonia and improve outcomes for intubated patients needing a gastric tube.
How similar studies have gone: Previous work suggests that tube placement site may influence infection risk, but evidence specific to VAP with this intervention is limited and further confirmation is needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient in intensive care, intubated, ventilated * Adult * Requiring a gastric tube * With an expected duration of mechanical ventilation of more than 48 hours * Affiliated to social security * Patient or relative consent or, failing that, emergency inclusion of the patient Exclusion Criteria: * Pregnant, breast-feeding or parturient women * Patients under legal protection: curatorship and guardianship * Contraindication to placing a gastric tube through the nose or mouth * Patients who already have a gastric tube when they enter the service * Patient intubated for more than 24 hours * Patient intubated via the nasotracheal route
Where it's running
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CHU Angers
Angers, France Recruiting -
CH Cholet
Cholet, France Recruiting -
CHU Grenoble
Grenoble, France Recruiting -
CHD Vendée
La Roche-sur-Yon, France Recruiting -
Centre Hospitalier Du Mans
Le Mans, France Recruiting -
APHM - Hôpital Nord
Marseille, France Recruiting
Show 10 more locations
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CHU Nantes
Nantes, France Recruiting -
CHRU Orléans
Orléans, France Recruiting -
APHP - Hôpital Saint-Antoine
Paris, France Recruiting -
CH Périgueux
Périgueux, France Recruiting -
CHU Poitiers
Poitiers, France Recruiting -
CHU Rennes
Rennes, France Recruiting -
CH Saint-Nazaire
Saint-Nazaire, France Recruiting -
CHRU Strasbourg - Hôpital de Hautepierre
Strasbourg, France Recruiting -
CHIC Toulon - La Seyne sur Mer
Toulon, France Recruiting -
CHRU Tours - Hôpital Bretonneau
Tours, France Recruiting
Study contacts
- Study coordinator: Christelle JADEAU
- Email: cjadeau@ch-lemans.fr
- Phone: +33244710781
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.