Gastric emptying in people with type 2 diabetes taking GLP-1 medicines
Official title: Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors Agonists
Run by University Hospital, Geneva · NCT07506356 · Data updated 2026-11-12
See if GLP-1 medicines like semaglutide slow stomach emptying in adults with type 2 diabetes and how that may affect anesthesia timing.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 38 (estimated) |
| Sponsor | University Hospital, Geneva Academic / other |
| Locations | 1 site (Geneva, Canton of Geneva) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | April 1, 2026 |
| Trial ID | NCT07506356 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with type 2 diabetes who have been treated with a GLP-1 analog for more than three months, are not on insulin, have BMI ≤40, can lie flat and follow instructions, and can attend three visits at the hospital are ideal candidates.
✕Probably not a fit
People on insulin, with prior gastric surgery, known GI motility disorders, hiatal hernia, BMI >40, inability to stop smoking 12 hours before measurements, or inability to lie down or follow instructions are unlikely to be eligible or benefit from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project at Geneva University Hospitals will use gastric ultrasound to measure how much food remains in the stomach of people with type 2 diabetes who have been on GLP-1 analogs for more than three months. Thirty-eight participants will attend three ultrasound visits over a seven-day period to track gastric content after routine meals and fasting. People on insulin, with prior gastric surgery or known gastrointestinal motility disorders, or who cannot lie flat or follow instructions are excluded to keep measurements reliable. The goal is to define how long GLP-1 drugs influence gastric emptying so clinicians can make safer decisions about when to stop these medicines before anesthesia.
Why it matters
Potential benefit: If successful, the results could give clear guidance on how long to stop GLP-1 medicines before anesthesia to reduce the risk of pulmonary aspiration.
How similar studies have gone: Previous studies have shown that GLP-1 agonists slow gastric emptying, but specific evidence guiding how long to stop these drugs before surgery is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female/ Male of 18 years old or more * With Type 2 Diabetes * Treated with GLP 1 analog for more than 3 months * Signed consent * ASA between I and IV Exclusion Criteria: * Insuline treatment * Gastro intestinal motility disorders * Past gastric surgery * Hiatal hernia * Recent trauma * Inability to be lay down for the exam * Inability to follow the instructions for the exam (language, dementia) * BMI \> 40 * Inability to stop smoking 12h before the measures
Where it's running
-
Hôpitaux Universitaires de Genève
Geneva, Canton of Geneva, Switzerland Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.