Game-based training to improve arm function after stroke

EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

NA · VA Office of Research and Development · NCT05628324

This study is testing if a fun gaming approach can help people who have had a stroke improve their arm function through practice and muscle training.

Quick facts

PhaseNA
Study typeInterventional
Enrollment62 (estimated)
Ages18 Years and up
SexAll
SponsorVA Office of Research and Development (fed)
Locations1 site (Charleston, South Carolina)
Trial IDNCT05628324 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate whether upper limb task practice and muscle activity training can enhance upper limb function in individuals who have experienced a stroke. Participants will attend the laboratory 23 times over a period of 2.5 months, engaging in activities designed to retrain muscle activation patterns and improve functional abilities. The intervention includes both practice of specific tasks and assessments of upper extremity function, utilizing an EMG-controlled gaming approach to facilitate rehabilitation.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who have experienced a stroke more than six months prior and have moderate unilateral upper limb impairment.

Not a fit: Patients currently undergoing upper limb rehabilitation or those with severe sensory loss or other comorbidities affecting upper limb movement may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve arm function and quality of life for stroke survivors.

How similar studies have performed: Other studies have shown promise in using task practice and EMG feedback for rehabilitation, suggesting potential for success in this novel approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18+ years old
* Stroke more than 6 months ago
* Moderate unilateral upper limb impairment
* Cognitive ability to participate in the study procedure
* Ability to see the full computer screen

Exclusion Criteria:

* Concurrent upper limb rehabilitation
* Inability to voluntarily contract muscles of at least 2 upper limb muscle groups, prohibiting participation in training
* Change in spasticity medication or botulinum toxin injection in the upper limb within 3 months prior to or during enrollment
* Total sensory loss
* Comorbidity (e.g., orthopaedic or premorbid neurologic condition) that limit upper limb movement and/or participation in the intervention
* Language barrier or cognitive impairment that precludes providing consent

Where this trial is running

Charleston, South Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Stroke, upper limb, rehabilitation, EMG muscle activation pattern, serious game, virtual reality, biofeedback

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.