Gallotannin-rich mango extract and a Lactiplantibacillus pentosus probiotic for gut microbes and inflammation in obesity
Exploring Tannin-Probiotic Interactions on Microbial Composition and Inflammatory Outcomes in Obesity
We will test whether mango-derived gallotannins, a Lactiplantibacillus pentosus probiotic, or both together change gut bacteria and lower inflammation markers in adults with obesity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Prairie View A&M University Academic / other |
| Locations | 1 site (Prairie View, Texas) |
| Trial ID | NCT07505212 on ClinicalTrials.gov |
What this trial studies
This interventional project uses stool samples from adults with obesity and a lean control group to examine how a gallotannin-rich mango extract and L. pentosus probiotic affect the gut microbiome and inflammation in vitro. Samples will be treated with GT extract alone, probiotic alone, the combination, or no treatment, and analyzed for changes in microbial taxa, gallotannin metabolism, and inflammation-related biomarkers. The study also explores whether individual genetic differences predict the ability to metabolize gallotannins. Findings will be used to identify microbial or molecular signatures linked to anti-inflammatory effects.
Who should consider this trial
Good fit: Adults 18–55 years old who are lean (BMI 18–24.9) or obese (BMI 30–40) without recent major illnesses, recent antibiotic use, or contraindicating conditions are the intended participants.
Not a fit: People outside the age or BMI ranges, those with recent antibiotic therapy, major cardiac/liver/kidney disease, pregnancy, active infections, or other exclusionary conditions are unlikely to be eligible or to benefit from the interventions tested.
Why it matters
Potential benefit: If successful, the findings could point to dietary or probiotic approaches to reduce obesity-related inflammation and help guide personalized interventions.
How similar studies have performed: Previous small studies of polyphenols and some probiotics have shown mixed but promising effects on the microbiome and inflammation, while gallotannin-specific combinations remain relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants will be screened by a study before being included in the study using the following inclusion criteria. Participants must be lean or obese male or female aged 18-55 years, within the BMI ranges 18- 24.9 kg/m2 (lean) and 30-40 kg/m2 (obese) will be included. Participants will be measured for anthropometric parameters such as height and weight to confirm their BMI before being registered for the study. Exclusion Criteria: * Participants with history of acute cardiac events, stroke, or cancer, recurrent hospitalizations, drug treatment of listed conditions within 6 months before study begin, abuse of alcohol/substance, on medications against T2DM or related diseases, smoking \> 1 pack/week, seizures (all within the last 6 months) will be excluded from the study. * Participants with history of liver, intestinal or renal dysfunction, pregnancy or lactation, allergy against GTs, mangos, history of hepatitis B, C, or HIV, use of systemic antibiotics within 1 months of screening, participation in other interventional research study, intake of herbal dietary supplements.
Where this trial is running
Prairie View, Texas
- Collaborative Agricultural Research Center — Prairie View, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Janet Antwi, Doctor of Philosophy — Prairie View A&M University
- Study coordinator: Janet Antwi, Doctor of Philosophy
- Email: jaantwi@pvamu.edu
- Phone: 936-2612536
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.