Gait Adaptation Training for people with MS
Official title: Integrative Training Approach for Inducing Neuroplasticity in Multiple Sclerosis
Run by Rutgers, The State University of New Jersey · NCT07660601 · Data updated 2026-11-12
This pilot program tests a gait adaptation training approach to see if it helps improve mobility and thinking skills in adults with multiple sclerosis.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Rutgers, The State University of New Jersey Academic / other |
| Locations | 1 site (Newark, New Jersey) |
| Status | Recruiting |
| Started | January 31, 2025 |
| Main results expected | May 20, 2028 |
| Study ends | July 20, 2028 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT07660601 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 to 80 with a clinically definite MS diagnosis who can follow instructions in English and have adequate vision.
✕Probably not a fit
Patients with ongoing relapse, recent steroid treatment, or other neurological conditions affecting cognition or balance may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This early-phase study investigates whether a gait adaptation training program can alter brain-to-muscle and brain-to-brain connectivity in adults with MS. The trial combines a gait-focused intervention with basic physical training to address sensorimotor and cognitive deficits. Researchers will assess behavioral performance and neural characteristics to understand potential neuroplastic changes. Preliminary data from related work informs the rationale, though this will be one of the first trials to test this approach in pwMS. Enrollment is limited to adults with MS who can attend to a screen and follow instructions in English.
Why it matters
Potential benefit: If successful, participants may experience improved gait adaptation, mobility, and possibly cognitive function related to motor tasks.
How similar studies have gone: Previous rehabilitation studies in MS show promise for gait and cognitive improvements, but this exact gait adaptation training approach in pwMS is novel and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 to 80 yrs Clinically definite MS diagnosis Ability to attend to computer screen and follow instructions in English which will be assessed by MiniMental test requiring a participant to score \>24 (out of 30 max score) Right-handed as determined by research diagnostic criteria of the Edinburgh Handedness Inventory (Oldfield 1971) Self report of normal or corrected-to-normal vision Exclusion Criteria Psychiatric disorders, only those requiring treatment because the medications may affect brain activation Neurological disorder that may affect cognition, balance, and/or physical wellness such as brain injury, or stroke. Orthopedic injuries or neuromuscular disorder that may affect balance or mobility Engagement in other cognitive or physical training program while enrolled in this study Ongoing relapse (new or returning neurological symptoms) or steroid treatment during the 30 days preceding enrollment
Where it's running
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Stanley Bergen Building
Newark, New Jersey, United States Recruiting
Study contacts
- Principal investigator: Soha Saleh, PhD — Rutgers University
- Study coordinator: Soha Saleh, PhD
- Email: soha.saleh@rutgers.edu
- Phone: 9739720472
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.