Functional ability, sleep quality, and thinking skills in people with obesity hypoventilation syndrome
Investigation of the Relationship Between Functional Capacity, Sleep Quality, and Cognitive Functions in Individuals With Obesity Hypoventilation Syndrome
This study will test whether adults with obesity hypoventilation syndrome have changes in thinking skills and whether those changes relate to sleep quality and physical functioning.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 36 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Bezmialem Vakif University Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07147153 on ClinicalTrials.gov |
What this trial studies
This observational study will recruit adults aged 18–65 diagnosed with obesity hypoventilation syndrome and may include a comparison group with simple obesity without sleep apnea. Participants will undergo standardized cognitive testing, sleep-quality assessments (including sleep study data or questionnaires), and functional capacity testing as tolerated. Clinical data including daytime CO2 levels and body mass index will be recorded to characterize disease severity. Researchers will analyze relationships between cognitive performance, sleep quality, and functional capacity to identify patterns of impairment.
Who should consider this trial
Good fit: Adults aged 18–65 with a pulmonologist-confirmed diagnosis of OHS who can communicate in Turkish and complete cognitive and exercise testing are the best candidates.
Not a fit: People with other major respiratory, cardiovascular, neurological, orthopedic, or psychiatric conditions that prevent testing or independently affect cognition are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, the results could help clinicians recognize cognitive problems earlier in people with OHS and guide interventions to improve sleep and functional capacity.
How similar studies have performed: Previous work has shown cognitive deficits in obstructive sleep apnea, but cognitive function in OHS has been little studied, making this a relatively novel clinical question.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years * Diagnosed with OHS by a pulmonologist * For individuals with simple obesity: BMI between 30 and 40 kg/m², Apnea-Hypopnea Index (AHI) \< 5 on polysomnography, or STOP-Bang score \< 3 * Ability to communicate in written and spoken Turkish Exclusion Criteria: * Presence of any additional severe respiratory disease * Presence of orthopedic, neurological, cardiovascular, or respiratory conditions preventing exercise testing * For individuals with simple obesity: presence of OSAS risk factors such as severe snoring or witnessed apnea * Presence of any psychological or psychiatric disorder that could affect cognitive functions
Where this trial is running
Istanbul
- Istanbul University, Istanbul Faculty of Medicine — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Ayca Arslanturk-Yildirim, Msc
- Email: ayca.arslanturk@bezmialem.edu.tr
- Phone: +905312891352
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.