Fucoidan SIRT6 activator for healthy aging in prefrail older men

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an interventional, placebo-controlled study testing oral fucoidan, a SIRT6-activating supplement, in prefrail men aged 50–80 living in Singapore. Participants will receive fucoidan or placebo and undergo measurements of inflammatory markers, DNA methylation profiles, and other aging-related biomarkers, with some skin microbiome sampling that may require shaving prior to visits. The protocol enrolls English-literate, non-smoking males without major cardiovascular disease and allows up to two stable chronic conditions from a specified list. The study builds on preclinical and small clinical signals linking fucoidan to reduced inflammation and epigenetic modulation but directly examines effects on human DNA methylation and biological aging markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 50-80 years males;
2. Resident of Singapore (citizenship or permanent residency is not required);
3. Prefrail according to Fried frailty phenotype score;
4. English-literate who can understand, read and write in English;
5. Individuals without severe cognitive impairment, as determined by PI judgment;
6. Apparently healthy and non-smokers having not more than 2 of the following conditions. If the conditions are present they have to be stable:

   * Hypertension,
   * Hyperlipidemia,
   * Hyperglycemia,
   * Osteopenia/osteoporosis,
   * Osteoarthritis,
   * COPD,
   * Type 2 diabetes.

Subjects who agree to shave one day before each visit if he has dense facial hairs on their cheeks that could interfere with skin microbiome sampling.

Exclusion Criteria:

1. Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease);
2. Current cancer or non-stable chronic obstructive pulmonary disease (COPD);
3. Use of anticoagulant medication;
4. Consuming seaweed more than 3 times a week;
5. Having hairiness, moles, tattoos, scars, irritated skin, etc. on the face which could influence the investigation;
6. Having used within the 3 past weeks for more than 3 consecutive days any systemic or topical drugs related to antibiotics or having planned to use these treatments during the study;
7. Having a positive serology for HIV, HEPATITIS B, HEPATITIS C\*

   \*Subjects will undergo a serology test, which will be conducted at baseline and at the end of the intervention visit. Only for subjects who accepted to undergo skin microbiopsy sampling;
8. Subject with any contra-indication for skin microbiopsies:

   * hypersensitivity or any serious reaction to local anesthesia; (lidocaine/prilocaine), local antibiotics, and antiseptics,
   * with inherited or acquired hemostasis disorders,
   * having had any treatment which may affect the blood coagulation and hemostasis (anti-coagulant medications…),
   * having a history of wound healing defects (hypertrophic scars, keloids…).

Where it's running

• Yong Loo Lin School of Medicine, National University of Singapore
  Singapore, Singapore, Singapore Recruiting
• NUS Academy for Healthy Longevity, Level 6, MD 11, 10 Medical Dr, Yong Loo Lin School of Medicine, National University of Singapore
  Singapore, Singapore Not yet recruiting

Study contacts

• Study coordinator: Andrea Britta Maier, MD PhD
• Email: a.maier@nus.edu.sg
• Phone: +65 63793186

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.