Frailty in kidney transplant recipients and its link to chronic graft dysfunction
Official title: Study of Frailty Among Renal Transplant Recipients, Its Relation to Chronic Renal Allograft Dysfunction
Run by Alexandria University · NCT07181096 · Data updated 2026-11-12
This will test how common frailty is in people with kidney transplants and see if frail patients are more likely to have chronic graft dysfunction.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Alexandria University Academic / other |
| Locations | 1 site (Alexandria) |
| Status | Recruiting |
| Started | July 15, 2025 |
| Main results expected | December 15, 2025 |
| Study ends | January 15, 2026 |
| Registry record updated | September 18, 2025 |
| Trial ID | NCT07181096 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult kidney transplant recipients treated at Alexandria University with GFR >30 who are physically and mentally able to complete frailty assessments and do not meet exclusion criteria.
✕Probably not a fit
Patients who are pregnant, have active neoplasia, chronic liver disease, prior immunological disease, severe psychiatric disorder, lower-limb amputation, or a GFR ≤30 are excluded and unlikely to receive benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This protocol enrolls kidney transplant recipients at Alexandria University with estimated GFR >30 and applies standardized frailty assessments alongside routine clinical and laboratory data to determine prevalence. Investigators will compare frailty status with measures of chronic allograft dysfunction, including trends in GFR and relevant clinical history. The study records comorbidities such as diabetes and serum albumin and notes cognitive impairment and sarcopenia where present. Patients with active cancer, chronic liver disease, prior immunological disease, severe psychiatric illness, lower-limb amputation, pregnancy, or who are otherwise unable to participate are excluded.
Why it matters
Potential benefit: If successful, the findings could help identify transplant patients at higher risk of chronic graft problems so clinicians can target monitoring or supportive care.
How similar studies have gone: Previous studies in CKD and dialysis populations have consistently linked frailty to worse outcomes, and smaller transplant cohorts have suggested similar associations though larger confirmatory transplant-specific studies are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Renal transplanted patients with GFR more than 30 Exclusion Criteria: * Mentally or physically unfit patients. * Amputation of lower limb. * Active neoplasia, chronic liver disease, previous immunological disease. * Psychiatric disorders. * Pregnancy.
Where it's running
-
Faculty of Medicine, Aexandria University
Alexandria, Egypt Recruiting
Study contacts
- Principal investigator: Mohamed mamdouh Elsayed, MD — Associate professor
- Study coordinator: Mohamed mamdouh Elsayed, MD
- Email: dr_mohamedmamdouh87@yahoo.com
- Phone: 00201068055103
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.