Clinical trial Recruiting at 1 site Observational Ages 18 and up

Frailty and recovery after hip or knee replacement

Official title: The Role of Frailty in the Rehabilitation Pathway Following Hip or Knee Arthroplasty Surgery.

Run by Fondazione Don Carlo Gnocchi ETS · NCT07086716 · Data updated 2026-11-12

This project will see how frailty affects rehabilitation and recovery in people who have had elective hip or knee replacement.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment124 (estimated)
SponsorFondazione Don Carlo Gnocchi ETS
Academic / other
Locations1 site (Rovato, BS)
StatusRecruiting
StartedJune 3, 2025
Main results expectedJanuary 2027
Study endsDecember 2027
Registry record updatedJuly 25, 2025
Trial IDNCT07086716 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults who received elective primary hip or knee replacement, can understand instructions, gave consent, and are admitted to the rehabilitation ward within 10 days after surgery are ideal candidates.

Probably not a fit

Patients undergoing revision or non-elective arthroplasty, those enrolled in other studies, or those admitted to rehab more than 10 days after surgery are not eligible and are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective case-control project groups patients by type of arthroplasty (hip or knee) and by frailty status using the Primary Care Frailty Index from medical records. Frailty will be reassessed at rehabilitation admission (T0) and discharge (T1), with additional outcome data collected at 3 months (T2) and 1 year (T3). Outcomes cover body structure and function, activity level, patient satisfaction, and adverse events, with a focus on whether rehabilitation has a protective role for frail patients. The study is conducted at a single rehabilitation center and includes only elective primary arthroplasty patients who enter rehabilitation within 10 days of surgery.

Why it matters

Potential benefit: If successful, the findings could help tailor rehabilitation plans to reduce complications and improve recovery for frail patients after hip or knee replacement.

How similar studies have gone: Previous research shows frailty predicts higher complication and worse outcomes after joint replacement, but the specific protective effect of rehabilitation in frail patients has been little tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Received elective hip or knee arthroplasty;
* Ability to understand written and oral instructions;
* Gave consent to study participation.

Exclusion Criteria:

* Arthroplasty revision or not elective intervention;
* Participation in other studies;
* Hospitalized in the rehabilitation ward more then 10 days after surgery.

Where it's running

  • Centro "E. Spalenza - Don Gnocchi
    Rovato, Bs, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.