Fractional CO2 laser plus topical hyaluronic acid, vitamin C and sodium DNA to improve facial skin in people over 30
Official title: Fractional CO2 Laser-assisted Delivery of Hyaluronic Acid, Ascorbic Acid and Sodium DNA For Enhancing Facial Skin Quality in Individuals Over the Age of 30
Run by Instituto de Oftalmología Fundación Conde de Valenciana · NCT07376148 · Data updated 2026-11-12
This will test whether applying hyaluronic acid, vitamin C, and sodium DNA after a fractional CO2 laser session improves facial skin quality in people over 30 with photoaged skin.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 30 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Instituto de Oftalmología Fundación Conde de Valenciana Academic / other |
| Locations | 1 site (Mexico City, Mexico City) |
| Status | Recruiting |
| Started | November 7, 2025 |
| Main results expected | February 28, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | January 29, 2026 |
| Trial ID | NCT07376148 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 30 with moderate photoaging (SASSQ ≥12), Fitzpatrick skin types I–III, no contraindications to laser or the topical ingredients, and the ability to attend four in-person visits in Mexico City.
✕Probably not a fit
People with Fitzpatrick skin types IV–VI, active local infections or suspected malignant lesions, allergy to the study ingredients, hypersensitivity to fractional CO2 laser, pregnancy, or breastfeeding are excluded and unlikely to receive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study enrolls adults over 30 with moderate photoaging (SASSQ ≥12) and Fitzpatrick skin types I–III who can attend four clinic visits. After baseline consent, photos, and SASSQ scoring, participants receive a fractional CO2 laser followed immediately by topical hyaluronic acid, ascorbic acid, and sodium DNA. Follow-up visits at one week and four weeks post-treatment include repeat SASSQ scoring, photographic documentation, and adverse event monitoring. Results will be analyzed with repeated-measures ANOVA using IBM SPSS Statistics v29 with p<0.05 as the significance threshold.
Why it matters
Potential benefit: If successful, this approach could meaningfully improve skin elasticity, reduce wrinkles, pigmentation, and pore appearance beyond laser alone.
How similar studies have gone: Laser-assisted delivery of topical agents after fractional ablative resurfacing has shown improved penetration and clinical skin benefits in prior studies, but the specific combination of hyaluronic acid, vitamin C, and sodium DNA is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female subjects, over 30 years of age, with moderate skin changes associated with elasticity, wrinkles, roughness, pigmentation, erythema, and pore size; with at least 12 points on the SASSQ scale. Fitzpatrick skin type I-III. Participants who agree to take part in the protocol Exclusion Criteria: * Fitzpatrick skin type IV-VI. Local infections or inflammatory disorders.. Neoplasms suspected of being malignant. Allergy to hyaluronic acid, ascorbic acid, and sodium DNA. Hypersensitivity to fractional CO2 laser. Pregnancy or breastfeeding. Local or systemic adverse reaction
Where it's running
-
Instituto de Oftalmología F.A.P. Conde de Valenciana, I.A.P.
Mexico City, Mexico City, Mexico Recruiting
Study contacts
- Study coordinator: Daniel B Mejia Llanes MD, Medical Doctor
- Email: db.mejia@outlook.com
- Phone: +503 6420 5801
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.