Focal muscle vibration to limit leg muscle weakness during reduced use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use a unilateral lower limb suspension model to mimic hypoactivity and compare a 10-day focal muscle vibration (FMV) protocol versus no vibration. FMV targets muscle spindle afferents and can produce cortical and spinal adaptations that influence neural drive to muscle. The study will measure changes in muscle strength and neuromuscular excitability to determine whether FMV reduces deconditioning. If effective, FMV could be a simple, non-invasive countermeasure during periods of immobilization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women.
* Aged 18 to 45 years.
* Body Mass Index (BMI) between 18,5 and 24,9 kg/m².
* Engaging in at least 1.5 hours per week of physical activity (e.g., brisk walking, running, swimming, cycling).
* Provided informed consent after receiving detailed information about the study.
* Affiliated with or beneficiaries of a social security system

Exclusion Criteria:

* Chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory disorders.
* Personal history and/or risk factors for thrombosis.
* Use of antidepressant medications.
* Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study.
* Recent bone or ligament trauma within the past 12 months.
* Inability to perform the physical efforts required for the study.
* Recent participation in a sporting competition or intense, unusual physical activity within the past month.
* Corticosteroid treatment within the past 3 months.
* Any skin lesions at the planned vibrator application site.
* Simultaneous participation in another interventional medical study.
* Pregnant or breastfeeding women.
* Individuals unable to understand the purpose and conditions of the study or unable to provide informed consent.
* Individuals deprived of liberty or under guardianship

Where it's running

• Centre Hospitalier Universitaire
  Saint-Etienne, France Recruiting

Study contacts

• Principal investigator: Leonard Feasson, Phd — Centre Hospitalier Universitaire Saint-Etienne
• Study coordinator: Leonard Feasson, Phd
• Email: leonard.feasson@chu-st-etienne.fr
• Phone: (0)477120383

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.