Flow-controlled versus volume-controlled breathing during one-lung ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, prospective observational comparison of FCV and VCV in adult patients undergoing thoracic surgery requiring one-lung ventilation. Patients receive the ventilation mode routinely used at their center (FCV or VCV) without randomization or additional interventions. Intraoperative respiratory mechanics (dynamic compliance, airway and driving pressures) and arterial blood gas measures including PaO2/FiO2 are recorded and compared between groups. Secondary data include other oxygenation variables and perioperative respiratory events.

Why it matters

Who can join: the full rules

Inclusion Criteria Adult patients aged 18 years and older Patients undergoing thoracic surgery requiring one-lung ventilation (OLV) Requirement for one-lung ventilation for at least 30 minutes American Society of Anesthesiologists (ASA) physical status I-III Provision of written informed consent Patients ventilated with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine clinical practice

Exclusion Criteria Requirement for emergency surgery History of untreated asthma High pulmonary risk, defined as predicted postoperative FEV₁ \< 20 mL/kg in males and \< 18 mL/kg in females High cardiac risk, including advanced cardiomyopathy with left ventricular ejection fraction \< 30% Body mass index (BMI) \> 35 kg/m² Contraindication to total intravenous anesthesia (TIVA) Evidence of pulmonary infection prior to surgery Presence of other significant pulmonary pathologies (e.g., tuberculosis, bullous lung disease, bronchiectasis) Severe COPD (GOLD stage III-IV) or significant restrictive lung disease Age \< 18 years or \> 80 years, or pregnancy ASA physical status IV or higher Uncontrolled arrhythmia or history of myocardial infarction within the past 3 months Inability to provide informed consent

Where it's running

• Health Sciences University Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital
  Ankara, Yenimahalle, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ökkeş Hakan Miniksar, Assoc.Prof
• Email: hminiksar@yahoo.com
• Phone: +905304686718

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.