Flow-controlled versus volume-controlled breathing during one-lung ventilation
Comparison of the Effects of Flow-Controlled Ventilation (FCV) and Volume-Controlled Ventilation (VCV) on Respiratory Mechanics and Gas Exchange During One-Lung Ventilation: A Multicenter Prospective Observational Study (FCVOLVent)
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · NCT07392086
This project tests whether flow-controlled ventilation (FCV) or standard volume-controlled ventilation (VCV) gives better lung mechanics and oxygenation in adults having one-lung ventilation for thoracic surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital (other) |
| Locations | 1 site (Ankara, Yenimahalle) |
| Trial ID | NCT07392086 on ClinicalTrials.gov |
What this trial studies
This is a multicenter, prospective observational comparison of FCV and VCV in adult patients undergoing thoracic surgery requiring one-lung ventilation. Patients receive the ventilation mode routinely used at their center (FCV or VCV) without randomization or additional interventions. Intraoperative respiratory mechanics (dynamic compliance, airway and driving pressures) and arterial blood gas measures including PaO2/FiO2 are recorded and compared between groups. Secondary data include other oxygenation variables and perioperative respiratory events.
Who should consider this trial
Good fit: Adults aged 18 or older undergoing elective thoracic surgery that requires at least 30 minutes of one-lung ventilation, with ASA physical status I–III and able to give informed consent are the intended participants.
Not a fit: Patients requiring emergency surgery or those with severe pulmonary or cardiac risk factors (e.g., severe COPD, very low predicted postoperative FEV1, advanced cardiomyopathy), high BMI, active pulmonary infection, or other excluded conditions are unlikely to benefit or are not eligible.
Why it matters
Potential benefit: If FCV shows better mechanics and oxygenation, it could reduce intraoperative lung stress and improve oxygen levels during thoracic surgery.
How similar studies have performed: Previous experimental work and limited clinical reports suggest FCV may improve lung recruitment and gas exchange compared with conventional modes, but evidence is still limited and not widely confirmed.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria Adult patients aged 18 years and older Patients undergoing thoracic surgery requiring one-lung ventilation (OLV) Requirement for one-lung ventilation for at least 30 minutes American Society of Anesthesiologists (ASA) physical status I-III Provision of written informed consent Patients ventilated with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine clinical practice Exclusion Criteria Requirement for emergency surgery History of untreated asthma High pulmonary risk, defined as predicted postoperative FEV₁ \< 20 mL/kg in males and \< 18 mL/kg in females High cardiac risk, including advanced cardiomyopathy with left ventricular ejection fraction \< 30% Body mass index (BMI) \> 35 kg/m² Contraindication to total intravenous anesthesia (TIVA) Evidence of pulmonary infection prior to surgery Presence of other significant pulmonary pathologies (e.g., tuberculosis, bullous lung disease, bronchiectasis) Severe COPD (GOLD stage III-IV) or significant restrictive lung disease Age \< 18 years or \> 80 years, or pregnancy ASA physical status IV or higher Uncontrolled arrhythmia or history of myocardial infarction within the past 3 months Inability to provide informed consent
Where this trial is running
Ankara, Yenimahalle
- Health Sciences University Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital — Ankara, Yenimahalle, Turkey (Türkiye) (RECRUITING)
Study contacts
- Study coordinator: Ökkeş Hakan Miniksar, Assoc.Prof
- Email: hminiksar@yahoo.com
- Phone: +905304686718
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: One-lung Ventilation, Thoracic Surgery, Respiratory Mechanics, Flow-Controlled Ventilation, Thoracic Anesthesia, Volume-Controlled Ventilation, One-Lung Ventilation