Flexible versus semi-rigid ureteroscopy for upper ureteric stones under 2 cm
Official title: Semi-rigid Ureteroscopy Versus Flexible Ureteroscopy in Upper Third Ureteric Stones Management: a Prospective Randomized Trial
Run by Assiut University · NCT07247617 · Data updated 2026-11-12
This will test whether flexible or semi-rigid ureteroscopy works better for adults with upper ureteric stones smaller than 2 cm.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut, Asyut Governorate) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | January 1, 2027 |
| Registry record updated | November 25, 2025 |
| Trial ID | NCT07247617 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with a single upper ureteric stone ≤20 mm and no associated renal stones or anesthesia contraindications are ideal candidates.
✕Probably not a fit
Patients with associated renal (kidney) stones, stones larger than 20 mm, pediatric patients, or those who cannot undergo anesthesia are unlikely to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with upper ureteric stones ≤20 mm who meet eligibility will undergo either flexible or semi-rigid ureteroscopy according to the trial protocol, with stone fragmentation typically performed using holmium laser lithotripsy. The study will record outcomes including stone-free rate, complications, operative time, and cost data to compare efficacy, safety, and cost-effectiveness between the two approaches. Key factors such as stone size, impaction, ureteric anatomy, and need for ureteric dilation will be tracked because they influence the choice and success of each approach. Patients with associated renal stones or contraindications to anesthesia are excluded to keep the comparison focused on isolated upper ureteric stones.
Why it matters
Potential benefit: If successful, the comparison could help surgeons choose the less invasive and more cost-effective option for specific upper ureteric stones, improving stone-free rates and reducing unnecessary use of flexible scopes.
How similar studies have gone: Previous reports indicate flexible ureteroscopy generally achieves higher stone-free rates (about 90–93%) but at higher cost and longer operative time versus semirigid ureteroscopy (about 81–90%), so this builds on existing comparative evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients ≥18 years * upper ureteric stone * ≤20 mm Exclusion Criteria: * Associated renal stones * Any contraindications to Anesthesia
Where it's running
-
Assiut Hospital
Asyut, Asyut Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Omar Ahmed Hamada Ali
- Email: omarahmedhamada74@gmail.com
- Phone: +201092868286
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Tamsulosin 0.4 mg with Tadalafil 5 mg versus 2.5 mg to reduce symptoms from ureteral stents
This will test whether adding Tadalafil at 5 mg or 2.5 mg to Tamsulosin 0.4 mg better reduces stent-related symptoms for adults with a double-J ureteral stent after stone removal.
-
Comparing two types of ureteral access sheaths for treating kidney stones
This study is testing whether a new bendable suction tool works better than a standard tool for helping patients with kidney stones get them removed safely during a specific procedure.
-
Using aminophylline to improve ureteral access for kidney stones
This study is testing if using aminophylline can help people who have had trouble with kidney stone removal through a specific procedure to make it easier and safer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.