Flavonoid foods and carbonyl stress: effects of high vs low flavonoid intake
Official title: Effects of Flavonoid-rich Foods on Carbonyl Stress
Run by North Carolina Agriculture & Technical State University · NCT07767149 · Data updated 2026-11-12
This study tests whether a high-flavonoid diet changes flavonoid biomarkers and lowers carbonyl stress in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 70 Years |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | North Carolina Agriculture & Technical State University Academic / other |
| Locations | 1 site (Kannapolis, North Carolina) |
| Status | Recruiting |
| Started | September 2, 2026 |
| Main results expected | October 15, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT07767149 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 25-70 without allergies to test foods and with normal blood and urine tests who are non-smokers and not on medications or antibiotics in the weeks surrounding the study.
✕Probably not a fit
Individuals with food allergies to test foods or those on regular medications or with recent antibiotic use may not benefit or be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In a randomized crossover design, healthy adults will follow two diets with different flavonoid levels—low (~140 mg/day) and high (~420 mg/day)—to see how flavonoid intake affects biomarkers in urine and plasma. Targeted LC-MS metabolomics will measure known and novel flavonoid metabolites and flavonoid-derived, carbonyl-stress markers such as reactive carbonyl species (RCS) and advanced glycation end products (AGEs). Researchers will compare time- and dose-dependent changes and explore relationships between flavonoid conjugates and carbonyl stress. The study aims to establish metabolite markers for dietary flavonoid intake and its potential to reduce carbonyl stress.
Why it matters
Potential benefit: If successful, the study could support dietary strategies using flavonoid-rich foods to lower markers of carbonyl stress.
How similar studies have gone: Previous work has shown dietary flavonoids influence metabolomic profiles; this study applies targeted LC-MS metabolomics to link intake with carbonyl-stress markers, an approach with some precedent but still expanding.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 25-70 years * BMI between 18 and 30 * Have no known allergy to test food * Have no known allergies to green tea, apples, blueberries, soy milk, or pineapples * Be not engaging in high-intensity exercise * Having blood and urine clinical tests in the normal range. * Be not taking antibiotics for six months * Be not currently taking medication * No taking any prescription drugs * All flavonoid-enriched supplements should be avoided. The flavonoid-enriched supplements list includes soy isoflavones, Lipo-Flavonoid, Citrus Bioflavonoids Complex, Super Flavonoids, Super Antioxidants, Quercetin Supplement, Essential-C, flavonoids, and milk thistle. Also other flavonoid supplements, including but not limited to luteolin, Rutin, etc. * No drugs or supplements within three weeks of the experiment * Be nonsmoking * Have no alcoholic intoxication * No alcoholic addiction * \< 3-4 drinks per week (less than 2 glasses (300 mL) per drink) * No alcohol within three weeks of the experiment * Have no extended exposure to industrial wastes Exclusion Criteria: * Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders * Cancer patients * Currently diagnosed cancer patients will be excluded. * Medication-free for \>2 years could be considered.
Where it's running
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North Carolina Agriculture and Technical State University/ NRI Building
Kannapolis, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Shengmin Sang — North Carolina A&T State University Principal Investigator
- Study coordinator: Shengmin Sang
- Email: ssang@ncat.edu
- Phone: 704-250-5710
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.