Fixing large-angle outward eye turn with either muscle transplantation or Y-splitting recession
Official title: Comparative Study of Muscle Transplantation Versus Y Splitting Recession Technique in Treatment of Large Angle Exotropia
Run by Ain Shams University · NCT07350330 · Data updated 2026-11-12
This trial will try two types of monocular eye-muscle surgery—muscle transplantation and Y-splitting recession—in people over 6 with large-angle exotropia (50–70 prism diopters).
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | October 30, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | January 20, 2026 |
| Trial ID | NCT07350330 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people older than 6 years with large-angle exotropia (50–70 PD), with myopic or hypermetropic refraction and no prior strabismus surgery or significant vertical/incomitant issues.
✕Probably not a fit
Patients with previous squint surgery, significant vertical or incomitant deviations, paralytic or restrictive disorders, neurological disease, or exotropia angles outside 50–70 PD are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional, single-center comparison tests two augmented recession techniques performed on one eye to correct large-angle exotropia: muscle transplantation versus Y-splitting recession. Eligible participants are older than 6 years with an exotropia angle of 50–70 prism diopters and may be myopic or hypermetropic. Key exclusions include prior strabismus surgery, significant vertical deviation, paralytic or restrictive squint, and any neurological disease. Surgeries and follow-up take place at Ain Shams University in Cairo with outcomes focused on ocular alignment and need for additional procedures.
Why it matters
Potential benefit: If successful, one of the techniques could produce better alignment with fewer repeat surgeries, improving both vision function and cosmetic appearance.
How similar studies have gone: Both muscle transplantation and Y-splitting have been reported in surgical case series to help correct large-angle exotropia, but direct head-to-head comparative data are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age should be of more than 6 years Exotropia of an angle ranging from 50 to 70 PD Myopic or hypermetropic refraction Exclusion Criteria: * history of previous squint surgery significant vertical deviation incomitant squint in the form of paralytic or restrictive disorder any neurological disease
Where it's running
-
Ain shams university
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Alaa mohsen Elmaghraby, masters
- Email: Alaa.Mohsen@med.asu.edu.eg
- Phone: +201115538151
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Effects of atropine eye drops on eye alignment and vision
This study is testing if low doses of atropine eye drops can help children aged 5 to 14 with eye alignment issues and myopia see better and slow down their vision problems.
-
Near-eye training to improve distance eye alignment in intermittent exotropia
A home-based 12-week program tests whether training the eyes at a distance can improve control of outward eye turn in children and young adults with intermittent exotropia, and whether wearing reading glasses during training helps more.
-
At-home dichoptic movies to improve eye alignment in children with intermittent exotropia
We will test whether watching dichoptic movies at home for eight weeks helps children with intermittent exotropia better control their eye alignment and reduce suppression.
-
True Muscle Transplantation vs Augmented Semi Hang-Back Recession for Large Angle Exotropia
A randomized trial tests whether true muscle transplantation works better than augmented semi hang-back recession for correcting large-angle exotropia in adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.